Saquinavir

Saquinavir and virologic efficacy

pretreatment PK parameters PD parameters

Gieschke et al. naïve (monother) AUC ? HIV-1 RNA wk 8

Hoetelmans et al. mixed conc. ratio ? HIV-1 RNA wk 48

Hoetelmans et al. naïve (quadruple) conc. ratio initial HIV-1 RNA decline (wk 2)*

Heeswijk et al. naïve (triple) none ? HIV-1 RNA wk 48

* Only in a univariate model

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