Indinavir

Indinavir and renal toxicity

• Anecdotal data show that high exposure to indinavir is associated with an increased risk for urological complaints (flank pain, haematuria, renal colic).

• It has been hypothesized that Cmax of indinavir is correlated with renal toxicity.

• Recent (preliminary) data of the BEST trial suggest that renal toxicity is more often encountered when used in a RTV/IDV 100/800 mg bid regimen as compared to IDV 800 mg tid alone, suggesting that AUC or time > certain concentration rather than Cmax might be the main determinant of renal toxicity1.

1Gatell, XIII IAC, Durban, 2000, abstract WeOrB484

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