PK-PD relationships for antiretroviral drugs

7/31/00


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Table of Contents

PK-PD relationships for antiretroviral drugs

PK-PD relationships

PK-PD relationships

Indinavir

Indinavir

Indinavir

Indinavir

Indinavir

Saquinavir

Saquinavir

Saquinavir

Saquinavir

Saquinavir

Nelfinavir

Nelfinavir

Nelfinavir and initial decline HIV-1 RNA

Nelfinavir

Nelfinavir

Nelfinavir

Ritonavir

Ritonavir

Nevirapine

Nevirapine

NVP PK-PD relationship

Efavirenz

Treatment outcome by subset of efavirenz concentration windows in studies 266-003/004/005/021/024

Efavirenz

Variability of exposure

Relevance of exposure

Relevance of exposure

Relevance of exposure

Relevance of exposure

Cmin/IC50 ratios

Cmin/IC50 ratios

From in vitro to in vivo?

IC50 versus EC50

Conclusions (1)

Conclusions (2)

Remarks (1)

Remarks (2)

Acknowledgements

Author: Richard Hoetelmans