Augmentin (cont)
In all settings, AUC and half-life comparable between new and old dosing regimens
Cmax higher by 50-80% in bid dosing regimens
T>MIC lower in bid regimens
- on average, bid regimens with 10 hours (out of 24)
- on average, tid regimens with 11 hours (out of 24)
- concerns also with 1/3rd lower beta-lactamase inhibitor activity