Coming Full Circle
Augmentin 7:1 NDAs (submitted in 1994/1995)
Adults: 500 mg tid to 875 mg bid of amoxicillin and 250 mg tid to 500 mg bid
Pediatrics: 40/mg/kg/day divided tid to 45 mg/kg/day divided bid of amoxicillin
In all formulations, clavulanic acid amount remained the same. Led to 1/3rd less daily clavulanate