Pediatric Dosing Example: Nelfinavir
Pediatric dose: 20-30 mg/kg TID
Compare to Adults: 750 mg TID
Age 2-7 yr (n=6) Age 7-13 yr (n=8)
AUC ? AUC ?
Cmax ? 30% Cmax ? 15%
Cmin ? ? 12% Cmin ? ? 16%
Greater PK variability in pediatric patients
No BID PK data available for pediatric patients. Thus, cannot extrapolate from adult BID safety and efficacy data.