Drug InteractionsPK Enhancers

• Simulated amprenavir concentrations

• APV/RTV 450/100 mg BID vs. APV 1200 mg BID:

  • APV AUC ?
  • APV Cmax ? 56%
  • APV Cmin ? 340%

• APV/RTV 600/100 mg BID vs. APV 1200 mg BID:

  • APV AUC ? 30%
  • APV Cmax ? 42%
  • APV Cmin ? 500%

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