Drug Interactions

• RIF 150 mg qd + IDV 800 mg q8hr vs. RIF 300 mg qd

  • RIF AUC ? 54%
  • RIF Cmax ?? 29%
  • 25-desacetyl-RIF AUC ? 300%
  • 25-desacetyl-RIF Cmax ?? 143%

• Recommendation:

  • Reduce RIF dose to one-half the standard dose when administered with IDV.

Previous slide

Next slide

Back to first slide

View graphic version