Cardiovascular Drugs That Prolong The QT Interval

5/23/01


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Table of Contents

Cardiovascular Drugs That Prolong The QT Interval

Issues

I. Approval for Atrial Arrhythmias

d, l,-Sotalol

Sotalol: Mean QTc Prolongatation and TdP

Sotalol: Effect on Mortality

Sotalol: Effect on Mortality

Dofetilide

Dofetilide: Dose-Effect on TdP and VF*

Dofetilide: Mortality Effect in High-Risk Population

Dofetilide: Mortality in Supraventricular Arrhythmia Trials

Dofetilide: Dose-Adjustment to Minimize Cardiac Toxicity

Dofetilide: Effect of Dose-Adjusting for Renal Fxn

Dofetilide/ Sotalol Summary

II. Approval As Second-Line Therapy

Bepridil

Bepridil

Bepridil: Summary

Division of Cardio-Renal Drug Products Summary/Conclusions

Division of Cardio-Renal Drug Products Summary/Conclusions

Division of Cardio-Renal Drug Products Summary/Conclusions

Author: Throckmorton