Profile Analysis of Cascade Impactor Data: An Alternative View

5/8/00


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Table of Contents

Profile Analysis of Cascade Impactor Data: An Alternative View

Comparing impactor distributions - Why and how

Physical significance of distribution differences

A model for investigations of F2 and c2 Changes in size distribution for a log-normal model

F2 variation as a function of MMAD and GSD relative to a reference distribution for the ACI

How F2 measures changes in size distribution

F250 Contours for relative change in MMAD and GSD

F250 Contours for relative change in MMAD and GSD

How c2 measures changes in size distribution

Theoretical total lung and alveolar deposition for an inhaled aerosol (GSD of 2) with and without a 5 second breath hold

 How changes in size distribution affect deposited dose

Comparison of F250 and 10% deposition contours

An alternative :Theoretical Deposition Fraction & weighted distributions

Weighted distributions and TDF for pMDI data

Weighting technique applied to label validation data

Issues with Weighting and TDF approach

Author: Andy Clark