Mean Change from Baseline inDiastolic Blood Pressure

StandingDBP(mm Hg)

Time — Post-dosing (Minutes)

SupineDBP(mm Hg)

* Statistically significant compared to Uprima® + ethanol at the p = 0.05 levels.

*

M98-838

Uprima® 6 mg + EtOH 0.3 g/kg

Uprima® 6 mg + Placebo

Placebo + EtOH 0.3 g/kg

• No clinically meaningful changes (N=66)

Phase I

Safety-Alcohol

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