Mean Change from Baseline inSystolic Blood Pressure

Time — Post-dosing (Minutes)

M98-838

SupineSBP(mm Hg)

StandingSBP(mm Hg)

Uprima® 6 mg + EtOH 0.3 g/kg

Uprima® 6 mg + Placebo

Placebo + EtOH 0.3 g/kg

• No statistically significant differences from ethanol alone (N=66)

Safety-Alcohol

Phase I

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