Ethanol Plus Uprima® 6 mg Mean Maximum Decrease from Baseline in Blood Pressure

Supine (mm Hg)

Systolic

Diastolic

Standing (mm Hg)

Systolic

Diastolic

Uprima®

Ethanol

M98-891(0.6 g/kg Ethanol) (N=61)

* Statistically significant at p = 0.05 level compared to Uprima® plus ethanol.

-14.0

-8.9

-16.6*

-9.5*

-10.9*

-6.5

-21.8

-12.6*

-14.7

-8.6

-23.2

-10.6*

-13.2

-7.8

-19.3

-12.1

M98-838(0.3 g/kg Ethanol)(N=64-66)

Ethanol

Uprima® +Ethanol

-15.9

-9.1

-26.8

-16.9

-15.2

-7.1

-22.3

-14.2

Changes for Uprima® + ethanol greater than ethanol alone in the standing position

Safety-Alcohol

Phase I