Ethanol Interaction Studies

• Study Design: Double-blind, randomized, placebo-controlled, three- period crossover studies in healthy male subjects

• Crossover periods: Ethanol Beverage + Uprima®  Placebo Beverage + Uprima®  Ethanol Beverage + Placebo

• Dose: Uprima® 6 mg M98-838, M98-891 Ethanol 0.3 g/kg M98-838 0.6 g/kg M98-891

• Day 1-3 Uprima® or placebo tablet

Day 3 Ethanol or placebo beverage, 1hr. before tablet

Washout Four days

Phase I

M98-838 & M98-891

Safety-Alcohol

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