Nitrates Plus Uprima® 5 mg Mean Maximum Decrease from Baseline in Blood Pressure

Supine (mm Hg)

Systolic

Diastolic

Standing (mm Hg)

Systolic

Diastolic

Uprima®

Uprima®

Placebo

Long-Acting

Nitrates

(N = 20)

* Statistically significant at p = 0.05 level compared to placebo.

-13.5

-6.0

-22.1

-8.9

-15.1

-6.7

-18.9*

-9.9*

-11.5

-4.9

-10.6

-5.1

-22.1

-11.6

-22.3

-13.9*

M98-930

Short-ActingNitrates

(N = 20)

Placebo

• Statistically significant differences only occurred in the standing position

Safety-Nitrates

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