Barbara Bopp, Ph.D. Manager, Drug Metabolism and Pharmacology

5/3/00


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Table of Contents

Barbara Bopp, Ph.D. Manager, Drug Metabolism and Pharmacology

Pharmacokinetics and Metabolism

Apomorphine Molecule

Sublingual Tablet

Plasma Concentration–Time Curves

Apomorphine Pharmacokinetics

Dose Proportionality: Cmax and AUCĄ

Distribution of Cmax Values from Uprima® (6 mg)

Apomorphine Plasma Concentrations in Elderly

Apomorphine Disposition

Major Metabolic Pathways for Apomorphine

Apomorphine and Cytochrome P450

Apomorphine Pharmacokinetics: Conclusions

Author: Andrea_Poffenberger