NICHD Perspective on Needs for the Study of Therapeutic Drug Use in Pregnancy

5/12/00


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Table of Contents

NICHD Perspective on Needs for the Study of Therapeutic Drug Use in Pregnancy

Issues

Therapeutic drug use is common and required in pregnancy for:

Maternal conditions commonly requiring therapy in pregnancy

Pregnancy-related conditions commonly requiring therapy

Fetal conditions commonly requiring drug therapy

Drug therapy in pregnancy

Pregnancy: Maternal physiologic changes affect therapeutic drug administration

Pregnancy: Cardiovascular changes

Pregnancy: Cardiovascular changes

Pregnancy: Cardiovascular changes

Gastrointestinal changes

Consequences of physiologic changes:

Consequences of physiologic changes:

Timing: Effect of gestational age

Maternal fetal transfer

Monitoring fetal drug levels

Ethical considerations & study design

NICHD & FDA Initiatives:

Bottom line

Author: Cathy Spong