Adverse Events(V303)

 CPT-11/5-FU/LV 5-FU/LV

Event (% of pts) N=199 N=186Diarrhea, grade 3/4 23 11

Grade 3 17 7

Grade 4 6 4

Vomiting, grade 3/4 6 3

Mucositis, grade 3/4 3 3

Neutropenia, grade 4 9 1

Neutropenic fever 5 1

Neutropenic infection 2 0

Discontinuations 9 3

Drug-related deaths 0.5 0

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