Treatment (V303)
Treatment continued until tumor progression or unacceptable toxicity
Supportive care for all study arms included:
- Atropine for the treatment of cholinergic symptoms
- Loperamide for the treatment of late diarrhea
- Antiemetics for the prophylaxis of nausea and vomiting
- Fluoroquinolone antibiotic for diarrhea in association with grade 4 neutropenia or neutropenic fever
Second-line, post-study chemotherapy permitted