Valproate in Dementia

• Uncontrolled studies

? N = 141

? All positive (2/3 rated as improved)

• Controlled studies

? N = 56 subjects with “agitation”

? 40% markedly improved

? N = 172 subjects with manic features

? Data under review

Porsteinsson et al, under review

Tariot et al, under review

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