HIV-1 p24 Antigen Testing Experience

During 2 years of testing 14 million donations (ARC), 136 samples were HIV-1 p24 Ag confirmed positive

• 58 were false positive (based on RNA negativity, lack of seroconversion, and nonreproducible Ag neutralization) = 1:241,379
• 74 were HIV Ab positive
• 4 were recently infected seroconverting donors
• As of November 1999, 5 seroconverting donors identified in 23 million donations
  • 1:4.6 million (ARC)
  • 1:9.2 million (US)

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