Table of Contents
Replacement of HIV-1 p24 Antigen Screening with HIV-1 RNA Nucleic Acid Testing (NAT) for Whole Blood Donations
Background
HIV-1 p24 Antigen Testing Experience
Samples for Testing
Comparison of HIV-1 p24 Ag Positive Window-Case U.S. Blood Donors
Detection of HIV-1 p24 Ag and NAT Yield Samples by HIV-1 NAT (1:128 Dilution)
HIV Panel 6240 – Virologic/Serologic Profile
HIV Panel 6240 – Virologic/Serologic Profile
HIV Panel PRB932 – Virologic/Serologic Profile
HIV Panel PRB932 – Virologic/Serologic Profile
HIV Panel PRB943 – Virologic/Serologic Profile
HIV Panel PRB943 – Virologic/Serologic Profile
Clinical Sensitivity, HIV Panels, Gen-Probe
Clinical Sensitivity, HIV Panels, Gen-Probe
Effect of Dilution on NAT Reactivity (Gen-Probe HIV-1/HCV Assay)
Gen-Probe Linked Study – Phase I External Control Panel
PPT Slide
Conclusions
Linear Relationship Between HIV RNA Levels and p24 S/CO Ratios
95% Prediction Limits for Relationship of HIV RNA Levels and p24 S/CO Ratios
HIV-1 RNA Levels During “RNA Only” and “p24 Positive” Window Periods
Linear Relationship Between HIV-1 RNA Levels and p24 S/CO Ratios in 32 Cases
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