Sitagliptin Renal Insufficiency Study
nDesign:      Open label, single dose
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nSubjects:   24 patients with renal insufficiency (6 mild, 6 moderate, 6 severe, and 6 end-stage renal disease (ESRD) on hemodialysis) as defined below, and 6 healthy concurrent control subjects
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nDose:       50-mg
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nAnalyte:   Sitagliptin
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nSamples:   Plasma up to 96 hr postdose; urine through 48 hr postdose
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Requiring hemodialysis
ESRD/hemodialysis
<30 mL/min/1.73 m2
Severe
30 to 50 mL/min/1.73 m2
Moderate
50 to 80 mL/min/1.73 m2
Mild
>80 mL/min/1.73 m2
Normal
24-Hour Creatinine Clearance
Degree of Renal Insufficiency