R. W. Johnson Pharmaceutical Research Institute
Overall Score for Relative Exposures: 0
Positive Signal: Dysmorphogenesis
While there is a difference in relative exposure ratios between the 2 species presented, a greater weight is placed upon the rat exposure ratio as this species metabolizes the drug most closely to humans.
a = concern is increased for relative exposure ratios (animal:human) that are ? 10, and are decreased for exposure ratios ? 25. Ratios between 10-25 are not associated with any change in the perception of concern for this factor.