R. W. Johnson Pharmaceutical Research Institute
Overall Score for Signal Strength Part A: +1
Positive Signal: Dysmorphogenesis
1) Cross Species Concordance Score = +1
Evidence from multiple species indicates concordance
2) Multiplicity of Effects Score = 0
Rats: skeletal (and associated soft-tissue) effects
Rabbits: skeletal effects only
3) Adverse Effects as a Function of Time Score = 0
The dysmorphogenic lesions observed in both rats and rabbits are related to susceptibility during the period of organogenesis