Aligarh Muslim University, Aligarh, India, B.Sc.(Hons), 1973, Chemistry,
Aligarh Muslim University, Aligarh, India, M.Sc., 1975, Chemistry (Organic)
Aligarh Muslim University, Aligarh, India, M. Phil, 1977, Chemistry (Neurochemistry)
Aligarh Muslim University, Aligarh, India, Ph.D., 1980 Chemistry (Neurochemistry/Neurotoxicology)

Experience:

• 1975-1979, Junior/Senior Research Fellow of CSIR, Brain Research Center, J.N. Medical College, Aligarh Muslim University, Aligarh, India.
• 1980-1981, Postdoctoral Research Fellow, of CSIR, Brain Research Center, J.N. Medical College, Aligarh Muslim University, Aligarh, India.
• 1981-1982, Fogarty International Fellow, Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
• 1982-1984, Postdoctoral Research Fellow/Research Associate, Departments of Pharmacology, Biochemistry and Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas.
• 1984-1986, Staff Fellow, Pharmacodynamics Branch, Division of Reproductive and Developmental Toxicolcogy, National Center for Toxicological Research, Jefferson, Arkansas.
• 1987-1992, Research Pharmacologist, Pharmacodynamics Branch, Division of Reproductive and Developmental Toxicolcogy, National Center for Toxicological Research, Jefferson, Arkansas.
• 1990, Acting Chief, Pharmacodynamics Branch, Division of Reproductive and Developmental Toxicolcogy, National Center for Toxicological Research, Jefferson, Arkansas.
• 1992-Present, Head, Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas.

Universities Affiliations:

• 1986 – Present, Adjunct Assistant, Associate and Full Professor, Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR
• 1990 – Present, Adjunct Professor, College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, FL
• 1991 – Present, Adjunct Full Professor, College of Pharmacy, Northeast Louisiana University, Monroe, LA
• 1995 – Present, Adjunct Associate Professor, Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR
• 1996 – Present, Adjunct Professor, Department of Pharmacology, Meharry Medical College, Nashville, TN

Honors:

• Zeneca Traveling Lectureship Award Sponsored by the Society of Toxicology, 1998
• Senior Scientist Award-Neuroscience Division, ASIOA, Society of Neuroscience Meeting, Los Angeles, 1998
• NCTR/FDA Scientific Achievement Award "Excellence in Laboratory Science", 1997
• FDA Award of Merit, 1997
• FDA Equal Opportunity Achievement Award, 1996
• Outstanding Service Award, 1995
• HRC, NCTR/FDA Outstanding Achievement Award, 1995
• FDA Special Act Award, 1995
• Federal Employee Quality Step Increases, 1988, 1992, 1993, 1994
• Fidia Research Foundation Travel Award, 1987 and 1989
• UNESCO/IBRO Travel Fellowship, 1983

Primary Research Interests:

• Role of oxidative stress and free radicals in neurodegeneration and neuroprotective mechanism of antioxidants.
• Cellular and molecular mechanisms of CNS-acting drugs, drugs of abuse and dietary supplements.
• Environmental agents, pesticides, organometals neurotoxicity and susceptibility to environmental agents in neurodegenerative diseases, aging and developmental neurotoxicology.
• MPTP-mouse model of Parkinson disease and neuroprotective role of nitric oxide inhibitor in neurodegeneration.

Recent Publications: (from a total of 200)

• Ali, S. F. and Kunio Y. Neurobiological base of stimulant-induced sensitization: from animal to man. Addiction Biology 5, 321-322, 2000.
  
  
• Ali, S.F., Haung, P. and Itzhak, Y. Role of peroxynitrite in methamphetamine-induced dopaminergic neurotoxicity and sensitization in mice. Addiction Biology 5, 331-341, 2000.
  

• Baumann, M.H., Rothman, R.B. and Ali, S.F Comparative neurobiological effects of ibogaine and MK-801 in rats. Drug and Alcohol Dependence 59, 143-151, 2000.
  
  
• Imam, S.Z., and Ali, S.F. Selenium, an antioxidant, attenuates methamphetamine-induced dopaminergic neurotoxicity and peroxynitrite generation. Brain Res. 855, 186--191, 2000.
  
  
• Ali, S.F. and Freyaldenhoven, T. MPTP-A model of Parkinson’s Disease. In: Chemical and Neurodegenerative Disease (Ed: S.C. Bondy), Prominent Press, Scottsdale, Arizona, 1999, pp. 1-28.
  
  
• Yui, K., Goto, K., Ikemoto, S., Ishiguro, T., Angrist, B., Duncan, G.E., Sheitman, B.B., Lieberman, J.A., and Ali, S.F. Neurobiological basis of relapse prediction in stimulant-induced psychosis and schizophrenia: the role of sensitization. Molecular Psychiatry 6, 512-523, 1999.
  
  
• Ali, S.F., Thiriet, N. and Zwiller, J. Acute ibogaine injection induces expression of the immediate early genes, egr-1 and c-fos, in mouse brain. Molecular Brain Res. 74, 237-241, 1999.
  
  
• Imam, S.Z.,Crow, J.P., Newport, G.D., Islam, F., Slikker, W. Jr., and Ali, S.F. Methamphetamine generates peroxynitrite and produces dopaminergic neurotoxicity in mice: protective effects of peroxynitrite decomposition catalyst. Brain Res. 837, 15-21, 1999.
  
  
• Yu, X., Imam, S.Z., Newport, G.D., Slikker, W. Jr., and Ali, S.F. Role of Ibogaine in methamphetamine-induced hyperthermia and dopaminergic neurotoxicity. Brain Res. 823: 213-216, 1999.
  
  
• Itzhak, Y, Martin, J.L., and Ali, S.F. Methamphetamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity in inducible nitric oxide synthase-deficient mice. Synapses 34: 305-312, 1999.
  
  
• Brenneman, K.A., Cattley, R.C., Ali, S.F. and Dorman, D.C. Manganese-induced developmental neurotoxicity in the CD rat: Is oxidative damage a mechanism of action?. Neurotoxicology 20: 477-488, 1999.
  
  
• Itzhak, Y., Martin, J.L., Black, M.D. and Ali, S.F. Effects of melatonin on methamphetamine- and MPTP-induced dopaminergic neurotoxicity and methamphetamine- induced behavioral sensitization. Neuropharmacology 37:781-791, 1998.
  
  
• Itzhak, Y., Ali, S.F., Martin, J.L., Black, Haung, P.L. The neuronal nitric oxide synthase is involved in the psychomotor and reinforcing properties of cocaine. Psychopharmacology 140:378-386, 1998.
  
  
• Itzhak. Y., Gandia, C, Haung, P.L. and Ali, S.F. Resistance of neuronal nitric oxide synthase-deficit mice to methamphetamine-induced dopaminergic neurotoxicity. Pharmacol. Exp. Ther. 284: 1040-1047, 1998.