Richard D. Beger, Ph.D., Division of Chemistry, National Center for Toxicological Research, FDA

Marquette University, B.S., 1983, Milwaukee, WI (Biomedical Engineering; Chemistry Minor)
Marquette University, M.S., 1986, Physics, Milwaukee, WI (Theoretical Solid State)
Purdue University, Ph.D., 1991, Physics, West Lafayette, IN (Theoretical Biophysics)

Experience:

• 1988-1990, NSF Predoctoral National Trainee, Department of Physics, Purdue University, West Lafayette, IN.
• 1991-1993, Postdoctoral Research Associate, Department of Biophysics and Biophysical Chemistry, John Hopkins Medical School, Baltimore, MD.
• 1993-1998, Postdoctoral Research Associate, Department of Chemistry, Wesleyan University, Middletown, CT.
• 1998-2000, Research Chemist, Division of Chemistry, National Center for Toxicological Research, Jefferson, AR.

Current Primary Research Interests: Molecular modeling and NMR structure determination.

• Producing spectrometric data-activity relationship models (SDAR)
• Producing quantitative spectrometric data-activity relationship models (QSDAR)
• Using MRS and artificial networks to build models that can predict cancer
• Using NMR to study metabolism of drugs

Most Recent Publications (from a total of 30 publications):

• Lundquist, A. J., Beger, R. D., Bennett, S. E., Bolton, P. H., Mosbaugh, D. W. Site-directed mutagenesis and characterization of Uracil-DNA glycosylase inhibitor protein. J. Biol. Chem. 272: 21408-21419 (1997).

• Beger, R. D. and Bolton, P. H. Structures of apurinic and apyrimidinic sites in duplex DNA. J. Biol. Chem. 273: 15565-15573 (1998).

• Beger, R. D. and Bolton, P. H. Protein phi and psi dihedral angle restraints determined from multi-dimensional hypersurface correlations of backbone chemical shifts and their use in the determination of protein tertiary structures. J Biomol. NMR 10: 129-142 (1998).

• Beger, R. D., Arthanari, H. B., Basu, S., and Bolton, P. H. Interresidue quiet-NOEs for DNA structural studies. Published with cover photo in J. Mag. Res. 132: 34-40 (1998).

• Beger, R. D., Marathias, V. M., Volkman, B. F., and Bolton, P. H. Determination of internuclear angles of DNA using paramagnetic assisted magnetic alignment. Published with cover photo in J. Mag. Res. 135: 256-259 (1998).

• Parshikov, I. G., Freeman, J. P., Lay, Jr., J. O., Beger, R. D., Williams, A. J., and Sutherland, J. B. Regioselective transformation of Ciproflaxacin to N-acetylciproflaxacin by the Fungus Mucor ramannianus. FEMS Micro. Lett. 177: 131-135 (1999).

• Beger, R. D., Freeman, J. P., Lay, Jr., J. O., Wilkes, J. G., and Miller, D. W. Producing ¹³C NMR, Infrared Absorption and EI Mass Spectrometric Data Monodechlorination Models of Chlorobenzenes, Chlorophenols, and Chloroanilines J. Chem. Inf. Comput. Sci. 40: 1449-1455, (2000).

• Beger, R. D., Freeman, J. P., Lay, Jr., J. O., Wilkes, J. G., and Miller, D. W. ¹³C NMR and EI Mass Spectrometric Data to produce a Predictive Model of Estrogen Receptor Binding Toxicology and Applied Pharmacology. 169: 17-25, 2000.

• Potuluri, J., Freeman, J. P., Heinze, T., Beger, R. D., and Cerniglia, C.Biotransformation of Vinclozolin by the Fungus Cunninghamella elegans.J. Agr & Food Chem. 48: 6138-6148, (2000).

• Lui, F. F., Ang, C. Y. W., Ranklin, J., Beger, R. D., Heinze, T., Freeman, J. P., and Lay, J. O., Jr. Evaluation of Major Active Compounds in St. Johns Wort Dietary Supplements by High Performance Liquid Chromatography with Photo-Diode Array Determination and Electrospray Spectrometric Confirmation. J. Chromatagraphy A. 888: 85-92, (2000).

• Parshikov, I. G., Freeman, J. P., Lay, Jr., J. O., Beger, R. D., Williams, A. J, and Sutherland, J. B. Microbiological transformation of Enrofloxacin by the Fungus Mucor ramannianus. Appl. Envirn. Microbiol. 66: 2664-2667. (2000).

• Bever Jr., R. J., Couch, L. H., Sutherland, J. B., Williams, A. J., Beger, R. D., Churchwell, M. I., Doerge, D. R., and Howard, P. C. DNA adduct formation by Fusarium culture extracts: Lack of a role for fusarin C. Chemico-Biol Interaction. 128: 141-157. (2000).

• Parshikov, I. G., Freeman, J. P., Lay, Jr., J. O., Beger, R. D., Moody, J. D., Williams, A. J, and Sutherland, J. B. Metabolism of the Veterinary Fluoroquinolone .Sarafloxacin by the Fungus Mucor ramannianus. J. Indust. Microbiol. Biotechol. 26: 140-144, (2001).

• Yang, Y. C., Yan, J., Churchwell, M., Beger, R., Chan, P.-C., Doerge, D. R., Fu, P. P., and Chou, M. W. Development of a 32P-postlabeling/HPLC method for detection of dehydroretronecine-derived DNA adducts in vivo and in vitro. Chem. Res. Toxic. 14: 91-100, (2001).

• Beger, R. D., Freeman, J. P., Lay, Jr., J. O., Wilkes, J. G., and Miller, D. W. The Use of ¹³C NMR Spectrometric Data to produce a Predictive Model of Estrogen Receptor Binding Activity J. Chem. Inf. Comput. Sci. 41: 219-224, (2001).

• Beger, R. D., and Wilkes, J. G. Developing ¹³C NMR quantitative Spectrometric data-activity relationship (QSDAR) Models to the Corticosteroid Binding Globulin. J. Comput.-Aided Molec. Design. 15: 659-669, (2001).

• Hur, H. G., Lay, J. O., Beger, R. D., Freeman, J. P., Rafii, F., Isolation and Characterization of an Anaerobic Intestinal Bacterium Capable of Cleaving a C-ring of Isoflavonoid Daidzein. Arch.Micro. In press.

• Beger, R. D. and Wilkes, J. G. Models of Polychlorinated Dibenzodioxins, Dibenzofurans, and Biphenyls Binding Affinity to the Aryl Hydrocarbon Receptor Developed Using ¹³C NMR Data. J. Chem. Inf. Comput. Sci. 41:1322-1329, (2001).

• Beger, R. D. Buzatu, D. A., Wilkes, J. G. and Lay, Jr. J. O. ¹³C NMR quantitative Spectrometric data-activity relationship (QSDAR) Models to the Aromatase Enzyme. J. Chem. Inf. Comput. Sci. 41:1360-1366, (2001).