UAS, Bangalore, India , B.Sc., 1983, Microbiology
West Texas A&M University, Canyon, Texas, M.S., 1985, Microbiology
Iowa State University, Ames, Iowa, Ph.D., 1990, Microbiology & Genetics

Experience:

• 1995 – Present, Research Microbiologist, Division of Genetic Toxicology, National Center for Toxicological Research, Jefferson, AR
• 1993 - 1995, Staff Fellow, Division of Genetic Toxicology, National Center for Toxicological Research, Jefferson, AR
• 1990 - 1993, Oak Ridge Associated Universities Postdoctoral Research Fellow, Div. of Genetic Toxicology, National Center for Toxicological Research, Jefferson, AR

Honors:

• FDA- Commendable Service Award: 2000
• FDA-Certificate of Appreciation: 1998, 1999
• Gamma Sigma Delta: 1988
• Academic Excellence Scholarship: W.T. A&M. University, 1984-1985
• National Merit Scholarship: 1974-1980
• Genetic Toxicology Representative to Research Scientist Council, National Center for Toxicological Research: 1997-1998
• Elected Secretary and Treasurer to Central Arkansas Chapter of Sigma Xi: 2000

Current Primary Research Interests:

• Validation of transgenic Big Blue (BB) rats by comparing transgene and an endogenous gene for mutational sensitivity.
• Risk analysis by genotoxicity screening of fish antibiotic Malachite green in transgenic BB rats.
• Evaluate effects of phytoestrogens, daidzein and genistein on the mutagenicity and carcinogenicity of the model mammary carcinogen DMBA in female ovariectomized BB rats.
• Evaluation of mutagenicity and carcinogenicity in prostate tissue of BB rats exposed to PhIP, a carcinogen from cooked meat

Recent Publications:

• M.G. Manjanatha, E.E. Li, P.P. Fu, and R.H. Heflich (1996). Comparison of ras mutations produced in liver tumors from B6C3F1 and CD-1 mice treated with benzo[a]pyrene, 6-nitrochrysene and 4-aminobiphenyl. J. Tox. Environ. Health 47: 195-208.

• M.G. Manjanatha, L.E. Lyn-Cook, S.J. Culp, F.A. Beland, R.H. Heflich, and A. Aidoo (1996). Lymphocyte mutant frequency in relation to DNA adduct formation in rats treated with tumorigenic doses of mammary carcinogen 7,12-dimethylbenz(a)anthracene. Mutation Research 357:89-96.

• R.H. Heflich, R.A. Mittelstaedt, M.G. Manjanatha, L.E. Lyn-Cook, and A. Aidoo (1996). DNA sequence analysis of Hprt mutations in lymphocytes from Sprague-Dawley rats treated with DMBA. Environ. Mol. Mutagen. 28:5-12.

• M.G. Manjanatha, J.B. Chen, J.G. Shaddock, Jr., A.J. Harris, S.D. Shelton, and D.A. Casciano (1996). Molecular analysis of lacI mutations in Rat2 cells exposed to DMBA: evidence for DNA sequence and DNA strand biases for mutation. Mutation Research 372:53-64.

• B.A. Smith, M.G. Manjanatha, I.P. Pogribny, R.A. Mittelstaedt, T. Chen, N.F. Fullerton, F.A. Beland, and R.H. Heflich (1997). Analysis of mutations in the K-ras and p53 genes of lung tumors and in the Hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene. Mutation Research 379:61-68.

• M.G. Manjanatha, S.D. Shelton, A. Aidoo, L.E. Lyn-Cook, and D.A. Casciano (1998). Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue rats treated with DMBA. Mutation Research 401:165-178.

• R.A. Mittelstaedt, M.G. Manjanatha, S.D. Shelton, L.E. Lyn-Cook, J.B. Chen, A. Aidoo, D.A. Casciano, and R.H. Heflich (1998). Comparison of the types of mutations induced by DMBA in the lacI and Hprt genes of Big Blue rats. Environ. Mol. Mutagen. 31:149-156.

• T. Chen, A. Aidoo, M.G. Manjanatha, R.A. Mittelstaedt, S.D. Shelton, L.E. Lyn-Cook, D.A. Casciano, and R.H. Heflich (1998). Comparison of mutant frequency and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue rats. Mutation Research 403:199-214.

• M.G. Manjanatha, S.D. Shelton, S.J. Culp, and D.A. Casciano (2000). DNA adduct formation and Molecular analysis of in vivo lacI mutagenesis in the mammary tissue of Big Blue rats treated with DMBA . Carcinogenesis 21: 265-273.

• S.D. Shelton , V. Cherry, and M.G. Manjanatha (2000). Mutant frequency and molecular analysis of in vivo lacI mutations in the bone marrow of Big Blue rats treated with DMBA. Environ. Mol. Mutagenesis (in press).