Tunghai University, Taichung, Taiwan B.S., 1964, Chemistry.
National Taiwan University, Taipei, Taiwan M.S., 1968, Biochemistry.
University of Medicine and Dentistry of New Jersey, Newark, N. J., Ph.D., 1978, Biochemistry.

Experience:

• Teaching/Research Associate, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
• Research Chemist, Veterans Administration Medical Center, Little Rock, Arkansas.
• Adjunct Assistant Professor, Chemistry Department , University of Arkansas at Little Rock, Little Rock, Arkansas.
• Research Chemist, Division of Chemistry, National Center for Toxicological Research, Jefferson, Arkansas.
• Research Chemist, Division of Nutritional Toxicology, National Center for Toxicological Research, Jefferson, Arkansas.
• 1996-present Research Chemist, Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas.
• 1990-present Adjunct Professor, Department of Environmental Health, Tongji Medical University, Wuhan, China.
• 1995-present Adjunct Professor, Department of Microbiology and Molecular cell Sciences, The University of Memphis, Memphis, TN.

Honors and Awards:

• Teaching Assistant Scholarship, Taiwan University, Taipei, Taiwan.
• Teaching Assistant Scholarship, UMDNJ, Newark, New Jersey.
• Postdoctoral Fellow, USUHS, Besthesda, Maryland.
• Best Paper Award, The American Society for Pharmacology and Experimental Therapeutics, 1984.
• Invited to direct a workshop on "In vitro and in vivo metabolism of xenobiotics" by the Ministry of Health, People's Republic of China and co-sponsored by Tongji Medical University, Wuhan, China, September, 1988.
• Distinguished Visiting Professor, Department of Public Health, China Medical University, Shenyang, China, 1990.

Current Primary Research Interests:

• Modulation of aflatoxin B1 toxicity and carcinogenesis.
• Effect of intermittent doses of AFB1 on AFB1-DNA adduct formation, gene mutation and AFB1-induced tumorigenesis.
• Structure-activity correlation of PAHs, nitro-PAHs and pyrrolizidine alkaloids.
• Genotoxic mechanisms of carcinogenesis in rats induced by pyrrolizidine alkaloids.

Most Recent Publications (from a total of 114 publications):

• Chung, K.-T., Lu, Z., and Chou, M.W. Mechanisms of inhibition tannic acid and related compounds to intestinal bacteria. Food Chem. Toxicol., 36: 1053-1060(1998).

• Kadlubar, F.F., Anderson, K.E., Haussermann, S., Lang, N.P., Barone, G.W., Thompson, P.A., MacLeod, S.L., Chou, M.W., Mikhailova, M., Plastaras, J., Marnett, L.J., Nair, J., Velic, I., and Bartsch, H. Comparison of DNA adduct levels associated with oxidative stress in human pancreas. Mutation Research, 405(2):1 25-33 (1998).

• Chen, R.M., Chou, M.W., and Ueng, T.H. Induction of cytochrome P450 1A in hamster liver and lung by 6-nitrochrysene. Archives of Toxicology, 72(7): 395-401 (1998).

• Morris, S.M., Aidoo, A., Chen, J.J., Chou, M.W., and Casciano, D.A. Aflatoxin B1-induced Hprt mutations in splenic lymphocytes of Fischer 344 rats. Results of an intermittent feeding trial. Mutation Research, 423(1-2): 33-8 (1999).

• Sotomayor, R.E., Ashu, S., Washington, M., Hinton, D.M., and Chou, M.W. Effects of intermittent and continuous exposure to aflatoxin B1 on DNA adduct formation and GST activity in the rat testis. Environ.Mol. Mutagenesis, 33: 293-302 (1999).

• Chou, M.W., Mikhailova, M.V., Nichols, J., Poirier, L.A., Warbritton, A., and Beland, F.A. Interactive effects of methyl-deficiency and dietary restriction liver cell proliferation and telomerase activity in Fischer 344 pretreated with aflatoxin B1. Cancer Lett., 152: 53-61(2000).

• Chung, K.-T., Chen, S-C., Wong, T.Y., Li, Y.-S., Lin, C.-M., Wei, C.-I., and Chou, M.W. Chromosmal Aberrations and Mutagenicity caused by benzidine and its analogues. Toxicol. Sciences, in press, (2000).

• Yang, Y.-C., Yan, J., Churchwell, M., Beger, R., Chan, P.-C., Doerge, D.R., Fu, P.P., and Chou, M.W. Development of a 32P-postlabeling/ HPLC method for detection of dehydroretronesine-derived DNA adducts in vitro and in vivo. Chem. Res. Toxicol., submitted.

• Yang, Y.-C., Yan, J., Doerge, D.R., Chan, P.-C., Fu, P.P., and Chou, M.W. Metabolic activation of the tumorigenic pyrrolizidine alkalois, riddelliine, leading to DNA adduct formation in vivo. Chem. Res. Toxicol., submitted.

• Banvalvi, G., Mikhailova, M., James, J., and Chou, M.W. Multiple S phase checkpoints: Fluctuation in DNA and poly-ADP-ribose synthesis in Chinese hamster ovary (CHO-K1) cells. Submitted to DNA and Cell Biology.