Eastern Illinois University, B.S., 1974, Zoology
Iowa State University, M.S., 1976, Genetics
Indiana University School of Medicine, Ph.D., 1981, Medical Genetics

• 1974-1976, Research/Teaching Assistant; Department of Genetics, Iowa State University, Ames, IA.
• 1976-1977, Research Assistant; Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, IN.
• 1977-1978, U.S.P.H.S. Predoctoral Trainee; Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, IN.
• 1978-1981, Research Assistant; Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, IN.
• 1981-1982, N.I.E.H.S. Postdoctoral Trainee; Department of Epidemiology and Public Health, Yale University, New Haven, CT.
• 1981-1982, Visiting Assistant Fellow; John B. Pierce Foundation Laboratory, New Haven, CT.
• 1982-1985, N.I.E.H.S. Postdoctoral Trainee; Department of Pharmacology, University of Texas Medical School, Houston, TX.
• 1985-1997, Research Biologist; Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR.
• 1997-present, Research Biologist; Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR.
• 1986-1995, Adjunct Assistant Professor, Department of Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR.
• 1995-present, Adjunct Associate Professor, Department of Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR.

Honors:

• 1989 NCTR Woman of the Year in Professional/Technical Category, in recognition of outstanding job performance and civic involvement, presented by NCTR Federal Women's Program, 1989.
• Food and Drug Administration Commissioner's Special Citation in recognition of outstanding basic research into the potential mechanism of action of teratogenic processes, 1989.

Current Primary Research Interests: Mechanisms of Developmental Toxicants

• Investigation of the genes in the folate metabolic pathway that are important in normal neural tube closure in mouse embryos.
• Role of the folate receptor in the mechanism of various birth defects.

Most Recent Publications (from a total of 4 publications):

• Holson, R.R., Bates, H.K., LaBorde, J.B. and Hansen, D.K. Behavioral teratology and dominant lethal evaluation of nitrous oxide exposure in rats. Neurotoxicol. Teratol., 17:583-592, 1995.

• Hansen, D.K., Dial, S.L. and Grafton, T.F. Lack of attenuation of valproic acid-induced embryotoxicity by compounds involved in one-carbon transfer reactions. Toxicol. In Vitro, 9:615-621, 1995.

• Hansen, D.K., Grafton, T.F., Dial, S.L., Gehring, T.A. and Siitonen, P.H. Effect of supplemental folic acid on valproate-induced embryotoxicity and tissue zinc levels in vivo. Teratology, 52:277-285, 1995.

• Bucci, T.J., Hansen, D.K. and LaBorde, J.B. Leukoencephalomalacia and hemorrhage in the brain of rabbits gavaged with mycotoxin fumonisin B1. Nat. Toxins 4:51-52, 1996.

• Hansen, D.K., Dial, S.L., Terry, K.K. and Grafton, T.F. In vitro embryotoxicity of carbamazepine and carbamazepine-10,11-epoxide. Teratology, 54:45-51, 1996.

• LaBorde, J.B., Terry, K.K., Howard, P.C., Chen, J.J., Collins, T.F.X., Shackelford, M.E. and Hansen, D.K. Lack of embryotoxicity of fumonisin B1 in New Zealand White Rabbits. Fundam. Appl. Toxicol., 40:120-128, 1997.

• Collins, T.F.X., Sprando, R.L., Hansen, D.L., Shackelford, M.E. and Welsh, J.J. Testing guidelines for evaluation of reproductive and developmental toxicity of food additives in females. Int. J. Toxicol. 17:299-325, 1998.

• Collins, T.F.X., Shackelford, M.E., Sprando, R.L., LaBorde, J.B., Hansen, D.K., Eppley, R.M., Trucksess, M.W., Howard, P.C., Bryant, M.A., Ruggles, D.I., Olejnik, N. and Rorie, J.I. Effects of fumonisin B1 in pregnant rats. Food Chem. Toxicol. 36:397-408, 1998.

• Collins, T.F.X., Sprando, R.L., Black, T.N., Shackelford, M.E., LaBorde, J.B., Hansen, D.K., Eppley, R.M., Trucksess, M.W., Howard, P.C., Bryant, M.A., Ruggles, D.I., Olejnik, N. and Rorie, J.I. Effects of fumonisin B1 in pregnant rats - Part 2. Food Chem. Toxicol. 36:673-685, 1998.

• Hansen, D.K. and Holson, R.R. "Developmental neurotoxicity of antiepileptic drugs". Handbook of Developmental Neurotoxicology, W.J. Slikker, Jr. and L.W. Chang, eds., San Deigo: Academic Press, pp. 643-660, 1998.

• Hansen, D.K., LaBorde, J.B., Wall, K.S., Holson, R.R and Young, J.F. Pharmacokinetic considerations of dexamethasone-induced developmental toxicity in rats. J. Tox. Sci., 48:230-239, 1999.

• Collins, T.F.X., Sprando, R.L., Shackelford, M.E., Hansen, D.K. and Welsh, J.J. Food and Drug Administration proposed guidelines for reproduction studies. Reg. Toxicol. Pharmacol. 30:29-38, 1999.

• Collins, T.F.X., Sprando, R.L., Shackelford, M.E., Hansen, D.K. and Welsh, J.J. Food and Drug Administration proposed guidelines for developmental toxicity studies. Reg. Toxicol. Pharmacol. 30:39-44, 1999.

• Antony, A.C. and Hansen, D.K. Hypothesis: Folate responsive-neural tube defects (NTDs) and neurocristopathies. Teratology, 62:42-50, 2000.

• Hansen, D.K., Barbee, S.A., Grafton, T.F., Gu, Y. and Streck, R.D. Antisense modulation of 5,10-methylenetetrahydrofolate reductase expression produces neural tube defects in mouse embryos. Reprod. Toxicol., submitted.

• Terry, K.K., Grafton, T.F., Streck, R.D. and Hansen, D.K. Valproic acid-induced changes in the expression of neural cell adhesion molecule during mouse neurulation. Teratology, submitted.