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K. Barry Delclos, Ph.D., Pharmacologist, Division of Biochemical Toxicology, FDA, National Center for Toxicological Research

Cornell University, A.B., 1976, Biological Sciences, Itheca, New York
Harvard University, Ph.D., 1982, Pharmacology, Cambridge, Massachusetts

Experience:

  • NRSA Predoctoral Trainee, Department of Pharmacology, Harvard University, Cambridge, MA
  • 1982-1985 Postdoctoral Fellow, McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI
  • 1985-1988 Staff Fellow, Division of Biochemical Toxicology, FDA, NCTR, Jefferson, AR.
  • 1989-Present Pharmacologist, Division of Biochemical Toxicology, FDA, NCTR, Jefferson, AR.
  • 1990-Present Adjunct Faculty, Interdisciplinary Toxicology Program, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences,

Honors:

  • FDA Commendable Service Award (Research in Chemical Carcinogenesis) , 1992.
  • FDA Award of Merit, 2000.

Current Research Interests: Hormonally active agents, endocrine disruptors.

  • Effects of hormonally active agents on structure and function of the reproductive tract and carcinogenesis.
  • Mechanisms of action of hormonally active agents.

Most Recent Publications:

  • Sams, R. II, Blaydes, B., Warbritton, A., Lomax, L.G., Bucci, T., Muskhelishvilli, L., and Delclos, K.B. Differences in the response to oxidative stress and mutant frequency in CD (Sprague-Dawley) and Fisher 344 rats due to an induced inflammatory response. Environ. Mol. Mutagenesis, 35: 336-342 (2000).
  • Dalu, A., Blaydes, B.S., Lomax, L.G., and Delclos, K.B. A comparison of the inflammatory response to a polydimethylsiloxane implant in male and female Balb/c mice. Biomaterials, 21: 1947-1957 (2000).
  • Flynn, K.M., Ferguson, S.A., Delclos, K.B., and Newbold, R.R. Effects of genistein exposure on sexually dimorphic behaviors in rats. Toxicol. Sci., 55: 311-319 (2000).
  • Doerge, D.R., Churchwell, M.I., and Delclos, K.B. On-line sample preparation using restricted-access media in the analysis of the soy isoflavones, genistein and daidzein, in rat serum using liquid chromato-graphy electrospray mass spectrometry. Rapid Commun. Mass Spectrom., 14: 673-678 ( 2000).
  • Ferguson, S.A., Flynn, K.M., Delclos, K.B., and Newbold, R.R. Maternal and offspring toxicity but few sexually dimorphic behavioral alterations result from nonylphenol exposures. Neurotoxicol. Teratol., in press.
  • Chang, H.C., Churchwell, M.I., Delclos, K.B., Newbold, R.R., and Doerge, D.R. Mass spectrometric determination of genistein tissue distribution in Sprague Dawley rats from dietary exposure. J. Nutrition, 130: 1963-1970 (2000).

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