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Georgia State University, B.S., 1975, Biology, Atlanta, Georgia
Clark Atlanta University, M.S. 1979, Microbiology
Clark Atlanta University, Ph.D., 1986, Cell Biology
Experience:
- 1977-1978: Graduate Research Training, Centers for Disease Control and Prevention,
Atlanta, GA
- 1978-1980 Laboratory Scientist, Georgia State Department of Health, Atlanta, GA
- 1980-1981 Laboratory Instructor, GA
- 1981-1982 Technician/Curator, Biology Department, Clark Atlanta University, Atlanta, GA
- 1984-1985 Teaching Assistant, Atlanta Junior College, Atlanta, GA
- 1986 Laboratory Instructor, Spelman College, Atlanta, GA
- 1986-1987 Research Associate, Endocrinology Laboratory, Clark Atlanta University,
Atlanta, GA
- 1987-1990 Oak Ridge Institute of Science and Engineering (ORISE) Post Doctoral Research
Fellow, Division of Genetic Toxicology, National Center for Toxicological Research,
Jefferson, AR
- 1989-present Adjunct Professor, University of Arkansas, Pine Bluff, AR
- 1990-1992 Senior Staff Fellow, Division of Genetic Toxicology, National Center for
Toxicological Research, Jefferson, AR
- 1992-1994 Research Biologist, Division of Genetic Toxicology, National Center for
Toxicological Research. Jefferson AR
- 1994-present Research Biologist (GS-13), Division of Genetic Toxicology, National Center
for Toxicological Research, Jefferson, AR
Honors:
- FDA Commendable Service Award, 2000
- Cash Award for Special Act of Service, 2000
- FDA Incentive Cash Awards, 1994-1999
- FDA Equal Opportunity Achievement Award, 1997
- NCTR EEO Outstanding Service Award, 1995
- Clark Atlanta University Best Research Award, 1989
- National Science Foundation Award, 1985-1986
- National Research Council Service Award. 1982-1985
- National Deans List, 1982
Current Primary Research Interests: Genetic & Reproductive Toxicology.
- The use of rat lymphocyte Hprt assay as a biomarker to investigate the mechanisms of
age-associated spontaneous and chemically induced mutations
- Influence of dietary supplements on the mutagenicity/carcinogenicity of environmental
genotoxicants, including food-borne carcinogens
- Mitochondrial DNA mutation
- Influence of dietary restriction on spontaneous mutation occurring in rodents and humans
Representative publications:
- Aidoo, A., Lyn-Cook, L.E., Mittlestaedt, R.A. Heflich, R.H.,
and Casciano, D.A. "Induction of 6-thioguanine-resistant lymphocytes in Fischer 344
rats following in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide."
Environ Mol Mutagen, 17:141-151 (1991).
- Aidoo, A., Lyn-Cook, L.E., Heflich, R.H., George, E.O., and
Casciano, D.A. "The effect of treatment time, treatment schedule and animal age on
the frequency of 6-thioguanine resistant T-lymphocytes induced in Fischer 344 rats by
N-ethyl-N-nitrosourea." Mutation Res., 298:169-178 (1993).
- Smith, A., Fullerton, N.F., Aidoo, A., Heflich, R.H., and
Beland, F.A. "DNA adduct formation in relation to lymphocyte mutations and lung tumor
induction in F344 rats treated with the environmental pollutant 1,6-dinitropyrene, Environ
Health Perspect., 99:277-280 (1993).
- Aidoo, A., Lyn-Cook, L.E., Lensing, S., and Wamer, W.
"Ascorbic acid (vitamin C) modulates the mutagenic effects produced by an alkylating
agent in vivo." Environ Mol Mutagen., 24:220-228 (1994).
- Aidoo, A., Lyn-Cook, L.E., Lensing, S., Bishop, M.E., Wamer,
W. "In vivo mutagenic activity of beta-carotene in rat spleen lymphocytes."
Carcinogenesis, 6:2237-2241 (1995).
- Casciano D.A., Chou, M., Lyn-Cook, L.E., and Aidoo, A.
"Calorie restriction modulates chemically induced in vivo somatic mutation
frequency." Environ Mol Mutagen., 27:162-164 (1996).
- Heflich, R.H., Mittelstaedt, R.A., Manjanatha, M.G.,
Lyn-Cook, L.E., and Aidoo, A. "DNA sequence analysis of Hprt mutations in lymphocytes
from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene." Environ Mol
Mutagen., 28:5-12 (1996).
- Manjanatha, M.G., Lyn-Cook, L.E., Culp, S.J., Beland, F.A.,
Heflich, R.H., and Aidoo, A. "Lymphocyte mutant frequency in relation to DNA adduct
formation in rats treated with tumorigenic doses of mammary carcinogen
7,12-dimethylbenz[a]anthracene." Mutations Res., 357:89-96 (1996).
- Desai, V.G., Lyn-Cook, L.E., Aidoo, A., Casciano. D.A., and
Feuers, R.J. "Modulation of antioxidant enzymes in bleomycin-treated rats by vitamin
C and b -carotene." Nutr Cancer, 29:127-132 (1997).
- Aidoo, A., Morris, S.M., and Casciano, D.A.
"Development and utilization of the rat lymphocyte Hprt mutation assay."
Mutation Res., 387:69-88 (1997).
- Manjanatha, M.G., Shelton, S.D., Aidoo, A., Lyn-Cook, L.E.,
and Casciano, D.A. "Comparison of in vivo mutagenesis in the endogenous Hprt gene and
the lacI transgene of Big Blue rats treated with DMBA." Mutation Res., 401:165-178
(1998).
- Chen, T.A., Aidoo, A., Manjanatha, M.G., Mittelstaedt, R.A.
Shelton, S.D., Lyn-Cook, L.E., Casciano, D.A., and Heflich, R.H. "Comparison of
mutant frequency and types of mutations induced by thiotepa in the endogenous Hprt gene
and transgenic lacI gene of Big Blue rats." Mutation Res., 403:199-214 (1998).
- Aidoo, A., Desai, V.G., Lyn-Cook, L.E., Chen, J.J., Feuers,
R.J., and Casciano, D.A. "Attenuation of bleomycin-induced Hprt mutant frequency in
female and male rats by calorie restriction." Mutation Res., 430:155-163 (1999).
- Casciano, D.A., Aidoo, A., Chen, T., Mittestaedt, R.A.,
Manjanatha, M.G., and Heflich, R.H. "Hprt mutant frequency and molecular analysis of
Hprt mutations in rats treated with mutagenic carcinogens." Mutation Res.,
431:389-395 (1999).
- Desai, V.G., Aidoo, A., Li, J., Lyn-Cook, L.E., Casciano,
D.A., and Feuers, R.J. "Effects of bleomycin on liver antioxidant enzymes and the
electron transport system from ad libitum-fed and dietary-restricted female and male
Fischer 344 rats." Nutr Cancer, 36:42-51 (2000).
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