NCTR Research Highlight - May 2, 2008

Science Advisory Board Review – A site visit team from the NCTR Science Advisory Board met at NCTR on April 29-30 for an in-depth analysis of research programs within the Division of Biochemical Toxicology.  The site visit team, led by Board Chair, Dr. James Popp, was comprised of subject experts from academia, industry, NIH, and each FDA product-line Center and ORA.

The Division presented results and future plans from studies on risk evaluation of food, drugs, and cosmetics.  Risk evaluations included:

·        tattoo inks

·        nano-scale titanium dioxide sunscreen

·        topically and orally administered Aloe vera

·        topically applied retinoic acid

·        nephrotoxicity of melamine/cyanuric acid combinations

·        transgenic models for melanoma

·        pyrrolizidine alkaloid-containing dietary/herbal supplements

·        the food contaminant acrylamide

·        multigenerational reproductive studies of estrogenic compounds

·        mixtures of anti-HIV/AIDS drugs

·        epigenetic mechanisms of carcinogenesis

·        varied PAH exposure used as surrogates for evaluating mixtures

·        idiosyncratic liver injury

The site visit report will be formally presented at the full NCTR Science Advisory Board meeting to be held at NCTR on August 12-13, 2008.

Research Highlight History