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Principal/

Co-Principal

Investigator(s)

Project

Number

Status/

Res. Area/

GOAL

Title
Ahn E0687001 Active/

Biometry/

METH

Nonparametric Estimation and Testing of the Tumor Incidence Rate in Survival/Sacrifice Experiments (CFSAN) (CDER)
Ahn E0691901 Active/

Biometry/

METH

Simulation Study on Reducing Conservatism in Risk Estimation for Mixtures of Carcinogens (CFSAN)
Ahn E0697101 Active/

Biometry/

CNPT

Tree-Structured Over-Dispersed Binomial and Over-Dispersed Poisson Regression Models
Aidoo E0676700

E0676711

Active/

Gen Tox/

PRED

Development of an Assay to Measure 6-Thioguanine-Resistant Rat T-Lymphocytes Treated with Mutagenic Agents in vitro (CDER) (CBER)
Aidoo E0681600 Active/

Gen Tox/

CNPT

Studies on Antioxidants: Evaluation of the Mutagenic Activity on N-Ethyl-N-nitrosourea (ENU) in the Rat (CFSAN)
Aidoo P00377 Active/

Gen Tox/

AGNT

Training for Mutagenesis Studies for ORISE Internship Program Participant
Aidoo E0685000

E0685011

Active/

Gen Tox/

PRED

Lymphocyte Mutation as a Biomarker for Mammary Tumors Induced by 7,12-Dimethylbenz(a)anthracene in Sprague Dawley Rats (CFSAN) (CDER) (CBER) (CDRH)
Aidoo E0697501

E0697511

Active/

Gen Tox/

PRED

The Frequency and Types of Spontaneous Mutations Found in the hprt and lacI Genes of Lymphocytes from Transgenic Big Blue Rats (CDER) (CBER)
Ali X50010 Proposed/

Neuro Tox/

AGNT

Iron-Induced Oxidative Stress
Ali E0683000 Completed/

Neuro Tox/

CNPT

Oxidative Stress-Induced Age-Related Neurotoxicity in Mice: Possible Mechanism of Action of METH and MPTP (CFSAN)
Ali E0688701

E0688711

Active/

Neuro Tox/

CNPT

Evaluation of Constitutive and Stress-Induced Levels of Expression of Heat-Shock Proteins in Cu/Zn- Superoxide Dismutase Transgenic Mice
Ali E0698301 Active/

Neuro Tox/

AGNT

Effects of Ibogaine on Neurotransmitter Systems, Generation of Free Radicals and Nitric Oxide Synthase Activity: Correlation with Neurohistological Evaluations in Mouse and Rat Brain (CDER)
Ali E0671900

E0671911

E0671921

Active/

Neuro Tox/

AGNT

Neurotoxicity Assessment of Prenatal, Postnatal, and Adult Exposure to Manganese in the Rat (CFSAN)
Allen E0698201 Active/

Chemistry/

METH

Development of Multi-Residue Method(s) for the Determination of Lead and Other Metals in Sweeteners and Edible Oils by Plasma Atomic Emission Spectrometry (CFSAN) (ORA)
Ambrosone X70017 Proposed/

Mol Epi/

METH

A Study of Breast Cancer in African-American Women: Innovative Recruitment and Novel Genetic and Environmental Risk Factors
Ambrosone X70016 Proposed/

Mol Epi/

METH

Determinants of Indolent and Invasive Prostate Cancer
Ambrosone E0697801 Active/

Mol Epi/

PRED

Chemical Carcinogenesis: Epithelial Cells in Breast Milk
Ang X60027 Proposed/

Chemistry/

METH

Development of Rapid Methods for Analysis of Vitamins in Feed Products
Ang E0693601

E0693611

Active/

Chemistry/

METH

Development of Analytical Methods for Determination of Amoxicillin and Lincomycin in Fish Tissues (CVM)
Arani E0697401 Active/

Biometry/

KNLG

Collinearity Under Proportional Hazards Model (CDER)
Arani X70046 Proposed/

Biometry/

METH

Adjusted P-values for Multiple Endpoints
Baker E0696901 Active/

R&D Tox/

KNLG

Enxymatic Oxidation of 17B-Estradiol: Role of the Products in Hormone Action (CFSAN)
Beland E0676000

E0676011

Completed/

Bio Tox/

AGNT

Incorporation of 3'-Azido-3'deoxythymidine into DNA of Target Tissues (CDER)
Beland P00371 Active/

Bio Tox/

AGNT

In Vivo DNA Adduct Standards
Beland E0673700

E0673701

Completed/

Bio Tox/

PRED

O-Acetylation of Carcinogenic N-Hydroxyarylamines
Beland P00364 Active/

Bio Tox/

AGNT

DNA Adducts of Tamoxifen (OWH)
Beland E0667000

E0667001

E0667002

Completed/

Bio Tox/

CNPT

Relationship Between Administered Dose, DNA Adduct, and Mutation Induction In Vivo
Beland X60035 Proposed/

Bio Tox/

AGNT

DNA Adducts from Tamoxifen
Beland X60031 Proposed/

Bio Tox/

PRED

O-Acetylation of Carcinogenic Hydroxyarylamines
Beland E0628900 Completed/

Bio Tox/

CNPT

Determination of Chemically-Induced Changes in DNA Structure and Sequence
Berg
(University of Arkansas for Medical Sciences)

Feuers

E0678800

E0678801

E0678820

Active/

Gen Tox, Cal Res/

AGNT

Acute Toxicity of Ganciclovir: Circadian Response and Effect of Dietary Restriction (CFSAN) (CDER) (CBER)
Billedeau E0698901 Active/

Chemistry/

METH

Development of Methods for Analysis of Volatile and Nonvolatile N-Nitrosamines in Relevant Cosmetics and Nitrite Cured Meat Products (CFSAN)
Binienda E0692301

E0692311

E0692321

Active/

Neuro Tox/

AGNT

3-Nitropropionic Acid (3-NPA) Hypoxia in them Rat: Neurochemical and Neurohistological Studies (CFSAN)
Binienda E0686901

E0686911

Completed/

Neuro Tox/

CNPT

The Effects of Prenatal Hypoxia on Postnatal Hippocampal Development in the Rat: Behavioral, Neurohistological and Neurochemical Studies
Bowyer E0690301

E0690311

Active/

Neuro Tox/

CNPT

Factors Affecting the Neurotoxicity of Amphetamines and Related Compounds (CDER)
Bowyer E0692601 Active/

Neuro Tox/

METH

Implementation of Molecular Biological Techniques for Assessing Changes in Neurogrowth/Neurotrophic Factors after Exposures to Neurotoxicants and Other Substances
Branham E0688501 Active/

R&D Tox/

KNLG

Effects of Therapeutic Antiestrogens on Postnatal Uterine Development in the Rat (CDER)
Campbell S00064 Active/

Micro/

RSUP

Microbiology Division-media Preparation
Carino E0699501 Active/

Mol Epi/

PRED

Characterization of Ovarian-Specific Biotransformation of Estradiol: A Model for the Identification of Inter-individual Variability in Tissue Specific Steroid Metabolism
Casciano E0678100 Active/

Gen Tox/

PRED

Metabolism and Induction of Mutations by the Fermented Food-Borne Carcinogen Urethane in the Transgenic Human Lymphoblastoid Cell H2D6 (CFSAN)
Casciano E0679500 Active/

Gen Tox/

PRED

Evaluation of Cytotoxic Properties of Chemical Components Associated with L-Tryptophan Contamination Using Transgenic Human Lymphoblastoid Cell Lines (CFSAN)
Casciano E0680500 Active/

Gen Tox/

CNPT

Does b-carotene Modulate the Effects of Carcinogens on Gene Expression (CFSAN)
Cerniglia E0678600 Active/

Micro/

PRED

Microbial Studies on Macronutrient Food Substitutes Phase I Validation Studies (CFSAN)
Cerniglia E0026200 Active/

Micro/

METH

Microbiological Diagnostic Methods: Development, Testing, & Evaluation
Cerniglia S00006

E0002200

E0010900

E0011000

E0011100

E0011200

E0011300

E0014500

E0023500

Active/

Micro/

RSUP

General Microbiological Support - Bacteriology, Parasitology, Mycology, and Virology
Chen S00188 Active/

Biometry/

RSUP

Research Scientists Council
Chen E0695801

E0695811

Active/

Gen Tox/

PRED

Mutant Frequencies and Types of Mutations Induced by Rat Carcinogens in the hprt and lacl genes of Big Blue Fischer 344 Rats (CDER) (CBER)
Chen E0690901 Active/

Biometry/

METH

A Linear Mixed Effects Model for Analysis of Data for Stability Studies (CDER)
Chen E0698401 Active/

Biometry/

METH

Statistical Analysis and Characterization of the Joint Actions of Toxicants
Chen P00348 Completed/

Bio Tox/

AGNT

In Vitro Granuloma Formation in Response to Biomaterials
Chen E0697701 Active/

Gen Tox/

PRED

Evaluation of Chemical-Induced Mutagenesis in Transgenic Mice Containing the fX174 am3 (CDER) (CBER)
Chou E0695201 In Review/

Bio Tox/

CNPT

Effects of Dietary Restriction on the Post-Initiation Stages in Aflatoxin B1 Induced Carcinogenesis on Male F-344 Rats fed Methyl-Deficient Diets (CFSAN)
Chou E0688801

E0688811

Active/

Bio Tox/

AGNT

A Collaborative Research Proposal to Assess Cancer Risk Posed by Intermittent Exposure to Aflatoxin B1 in Rats (CFSAN)
Chou E0260401

E0260412

Active/

Bio Tox/

CNPT

Effect of Caloric Restriction on DNA Binding and DNA Adduct Removal In Vivo
Coles E0697001

E0697011

Active/

Bio Tox/

CNPT

Sequence Specificity of DNA Adduct Formation and Removal Following Chronic Carcinogen Administration
Colvert E0684000 Active/

Micro/

METH

Detection of Clostridium Botulinum Using Enzyme Linked Immunosorbent Assay and Polymerase Chain Reaction Techniques (ORA)
Colvert E0684400 Active/

Micro/

METH

Production of Monoclonal Antibodies Against Vibrio Cholerae for Diagnostic Screening Tests: Establishment of Monoclonal Antibody Capabilities at NCTR (ORA)
Cooney E0960001 Active/

Mol Epi/

AGNT

Preliminary Assessment of Methyl Supplements, Metabolism, and DNA Methylation
Cooney E0698101 In Review/

Mol Epi/

CNPT

Investigation of Short Term Dietary Methyl Supplementation in Manipulation of DNA Methylation and Methyl Metabolism in Mice
Culp X00032 Proposed/

Bio Tox

AGNT

2-Year Bioassay on Malachite Green
Dass E0693301

E0693311

E0693321

E0693331

Active/

Gen Tox/

PRED

Tumor Prone P53-Deficient Transgenic Mice (TSG-p53TM): A Potential System to Augment the Sensitivity of Carcinogenicity Testing and for Studying the Mutational Basis of Tumors (CDER)(CBER)
Dass E0694801 Active/

Gen Tox/

PRED

In Vitro Induction of Mutation by Carcinogens in the HPRT Gene in Mouse T-Lymphocytes (CDER) (CBER)
Delclos P00347 Completed/

Bio Tox/

METH

The Rodent Air Pouch as a Model System for Evaluating Inflammation and DNA Damage Induced by Biomaterials
Delclos E0698601 Active/

Bio Tox/

CNPT

Serum Albumin Adducts as Markers of Exposure to Toluenediamines from Implanted Polyurethane Foam
Delclos E0699301 Active/

Bio Tox/

KNLG

Evaluation of Host Factors Contributing to Differences in the Response to Biomaterials (CDRH)
Delclos E0677500 Active/

Bio Tox/

AGNT

DNA Damage in Mammary Tissue, Liver and Nucleated Blood Cells of F344 Rats with Polyester Polyurethane (Microthane Foam) Implants (CDRH)
Delclos E0696301 Active/

Bio Tox/

AGNT

Sexual Dimorphism in the Inflammatory Response to Biomaterials
Dobrovolsky E0692701

E0692711

Active/

Gen Tox/

METH

Development and Validation of Mouse Embryonic Stem Cell Cultures for use in Generating Animal Models with Targeted Transgenes (CDER) (CBER)
Doerge X70035 Proposed/

Chemistry/

METH

LC/MS Determination of Fluroquinolone in Animal Hair
Doerge S00007 Active

Chemistry/

METH

General Chemistry Support
Doerge E0694501 Active/

Chemistry/

METH

Development of Methods for Analysis and Confirmation of B-Agonists (CVM)
Doerge E0692001 Active/

Chemistry/

CNPT

Toxic Hazards from Anti-Thyroid Chemicals (CVM)
Duffy P00355 Completed/

Cal Res/

CNPT

Effect of Age and Dietary Restriction in the Peromyscus Leucopus Mouse
Duffy S00143 Active/

Cal Res/

METH

Development of an Automated Repetitive Blood Sampling System to Measure Circadian Rhythms Of Blood Chemistries
Duffy S00136 Completed/

Cal Res/

RSUP

Peromyscus Leucopus Breeding Colony
Duffy

Lu

E0692401

E0692411

E0692421

In Review/

Cal Res/

CNPT

Effect of Different Levels of Caloric

Restriction on Physiological, Metabolic, Biochemical, Immunological, Molecular, and Body Composition Variables in Rats (CFSAN) (CDER)

Duffy E0684700 Completed/

Cal Res/

CNPT

Effects of Chronic Caloric Restriction, Exercise, and Isoproterenol on Cardiovascular And Metabolic Performance and Stress Proteins In Rats of Different Ages
Ekuban P00351 Completed/

Gen Tox/

METH

Training in Lymphocyte Mutagenesis and DNA Repair Assays for ORISE Visiting Scientist
Erickson E0696501 Active/

Micro/

METH

Development of an Improved Method for Determining the Tuberculocidal Activity of Chemical Disinfectants for Medical Devices
Evans E0692801 In Review/

Bio Tox/

CNPT

Metabolite Changes in Alzheimer Disease (AD) by 1H NMR
Evans E0693801 Active/

BioTox/

METH

Quantitative Determination of Enantiomers Composition and Purity of Drugs by NMR Spectroscopy (ORA)
Evans E0667900 Completed/

Bio Tox/

AGNT

Multinuclear NMR Studies on the Structure and Conformation of Metabolites and Adducts of Polycyclic Aromatic Hydrocarbons
Evans X60033 Proposed/

Bio Tox/

METH

NMR of Antidepressant Drugs
Evans E0688301 Completed/

Bio Tox/

METH

NMR Spectroscopy of Sulfonylurea Herbicides (ORA)
Ferguson E0663811

E0663813

E0663814

E0663815

E0663816

Active/

R&D Tox/

CNPT

The Effect of Neonatal Dexamethasone(DEX) Exposure on Brain and Behavior in the Rat
Ferguson E0673000

E0673002

E0673003

E0673004

E0673005

E0673061

Completed/

R&D Tox/

PRED

Use of the Rodent Operant Test Battery (OTB) To Assess Neurobehavioral Toxicity: Preliminary Studies
Ferguson P00339 Completed/

R&D Tox/

PRED

Training in the Use of Rodents in Behavioral Toxicology and Teratology and Gross Dissection Techniques
Ferguson E0690401

E0690411

Active/

R&D Tox/

PRED

Development of Techniques for Producing and Measuring Attentional Deficit Hyperactivity in Rats

(CFSAN) (CDER)

Ferguson S00169 Completed/

R&D Tox/

PRED

Rodent Behavioral Training in Various Tasks
Feuers E0699101 Active/

Gen Tox/

PRED

Influence of Dietary Restriction on Somatic Mutation and Antioxidant Enzymes Induced by Exposure of Female and Male Fischer 344 Rats to Bleomycin (CDER)
Feuers E0683400

E0683401

E0683402

Active/

Gen Tox/

CNPT

The Effect of Age and Food Restriction on Glutathione S-Transferase Isozymes in C57BL/6N Mice
Fishman E0688601 Active/

R&D Tox/

KNLG

In Situ Expression of Estrogen Receptor (ER) Protein and mRNA in the Developing Reproductive Tract (CDER)
Flammang P00268 Active/

Off Res

RSUP Research Support

NCTR/FDA Integrated Research (CFSAN) (CDER) (CDRH) (CVM) (CBER)
Frederick E0691401

E0691411

E0691421

Active/

Neuro Tox/

PRED

Validation of the NCTR Rodent Operant Test Battery as an Adjunct to the NCTR Primate Operant Test Battery: Implications for the Areas of Risk Assessment and Prediction of Neurobehavioral Toxicity
Frederick E0697901 Active/

Neuro Tox/

PRED

Validation of the NCTR Nonhuman Primate OTB as a Predictor of Neurobehavioral Toxicity II. Pharmacological Manipulation at Specific Neurotransmitter Receptor Subtypes
Frederick E0694301

E0694311

E0694321

Active/

Neuro Tox/

AGNT

Behavioral and Neurochemical Effects of Short Course, High Dose Exposure to Methylenedioxymethamphetamine (MDMA) or Dexfenfluramine (FEN) in Rhesus Monkeys
Freeman S00069 Active/

Chemistry/

RSUP

Equipment Calibration
Freni E0695401 Active/

Biometry/

CNPT

Resting Metabolic Rate, Body Composition, and Dietary Assessment
Freni E0686800 Active/

Biometry/

AGNT

Fluoride in Public Drinking Water Systems and Human Fetal Health
Freni E0687101 Active/

Biometry/

AGNT

Caloric Intake and Human Health (The NHANES-1 Study) (CFSAN) (CDER)
Fu X70008 Proposed/

Bio Tox/

METH

Studies on the Effects of Caloric Restriction on Chemically-Induced Lipid Peroxidation and DNA Adduct Formation and H-ras Oncogene Activation in Tumor Tissues (Newborn Mouse Program)
Fu X70006 Proposed/

Bio Tox/

METH

Study of Secondary Mechanisms: Lipid Peroxidation and Endogenous DNA Adducts Involved in Chloral Hydrate, Benzodiazepines, and Antihistamine Drugs (Newborn Mouse Program)
Fu E0657300

E0657301

E0657302

E0657303

E0657304

E0657305

E0657306

E0657307

E0657308

E0657312

E0657318

Active/

Bio Tox/

PRED

Tumorigenicity of Nitro-Polycyclic Aromatic Hydrocarbons (Nitro-PAHs) and their Metabolites in the Neonatal B6C3F1 Mouse
Fu X70009 Proposed/

Bio Tox/

METH

EPA-IAG
Fu E0666900 Active/

Bio Tox/

CNPT

Comparative Regioselective and Stereoselective Metabolism of 7-Chlorobenz[a]anthracene and 7-Bromobenz[a]anthracene by Mouse and Liver Microsomes
Fu E0671000 Completed/

Bio Tox/

CNPT

Effect of Caloric Restriction on Metabolism and DNA Binding of Nitro-Polycyclic Aromatic Hydrocarbons (PAHs)
Fu X70007 Proposed/

Bio Tox/

METH

Oncogene Analysis of PAH and Nitro PAH Tumors (Newborn Mouse Program)
Fu E0687901

E0687912

E0687913

E0687914

E0687915

E0687916

Active/

Gen Tox/

PRED

The Evaluation of Selected Benzodiazepine and Antihistamine Drugs in the Neonatal Mouse Tumorigenicity Bioassay and in Transgenic Human Lymphoblastoid Cells (CDER)
Fu X60030 Proposed/

Bio Tox/

CNPT

Effect of Caloric Restriction on Metabolism and DNA Binding of Nitropolycyclic Aromatic Hydrocarbons
Gaylor E0691101 Completed/

Biometry/

PRED

Correlation of Body Weight and Tumor Incidence in Female Mice
Gaylor E0691001 Active/

Biometry/

PRED

Upper Limit for the Sum of the Risks of the Components in a Mixture and an Optimum Strategy for Risk Reduction
Gaylor S00116 Active/

Biometry/

CNPT

Risk Assessment (General)

(CFSAN) (CDRH) (CVM)

Gaylor E0689301 Completed/

Biometry/

METH

Preliminary Estimate of Tumor Potency Based on the 90-Day Maximum Tolerated Dose (CFSAN) (CDER)
Gaylor S00032 Active/

Biometry/

CNPT

Interagency Projects
Gaylor S00009 Active/

Biometry/

CNPT

General Biometry Support
Gazzara E0699401 In Review/

R&D Tox/

CNPT

Efficacies and Relative Potencies of the Monoamine Uptake Inhibitors Cocain, Fluoxetine, and GBR 12909 in Preweanling Male and Female Rats as Measured by Cerebral Microdialysis
Gehring X60017 Proposed/

Chemistry/

METH

Multiresidue Determination of Sulfonamides in Fish
Gillam S00173 Active/

Neuro Tox/

METH

Procedure for Ambulation Exercise of Nonhuman Primates Using the Controlled Ambulation Device (CAD)
Griffin E0695501 Active/

Tech AdvTechnology Advancement/

AGNT

Accumulation of Manganese in Edible Muscle of Channel Catfish (Ictalurus punctatus) Following Exposure to Water (CVM)
Hammons E0696201 Active/

Mol Epi/

PRED

Methylation Profile, Gene Expression, and Enzyme Activity of CYP1A2 in Human Livers
Hammons E0683500 Completed/

Mol Epi/

METH

Characterization of Cytochrome P450IA2 through the Utilization of Photoaffinity Labeling
Hansen E0688101

E0688111

Active/

R&D Tox/

CNPT

Investigations on Carbamazepine (CBZ) Embryotoxicity In Vitro (CFSAN)(CDER)
Hansen S00137 Active/

R&D Tox/

RSUP

CD-1 Mouse Breeding Colony
Hansen E0698501 Active/

R&D Tox/

PRED

The Role of Reactive Intermediates in Carbamazepine-Induced Embryotoxicity (CDER)
Hansen E0691501 Active/

R&D Tox/

PRED

Stress Protein Expression Following Treatment with Developmental Toxicants In Vitro (CDRH)
Hansen E0698001 Active/

Chemistry/

METH

Development of Methods for Analysis and Confirmation of Erythromycin A Residues in Tissue Samples from Terrestrial- and Aquatic-Farmed Animals by Liquid Chromatography (CVM)
Hansen S00163 Active/

R&D Tox/

PRED

Embryo Culture Training
Hansen P00376 In Review/

R&D Tox/

PRED

Development of Limb Bud Culture System
Hansen E0686701

E0686711

Active/

R&D Tox/

PRED

Investigations on the Mechanism of Valproic Acid-Induced Embryotoxicity In Vitro (CFSAN) (CDER)
Hansen X70002 Proposed/

R&D Tox/

PRED

Antisense Oligonucleotides
Hansen E0696001 Active/

R&D Tox/

PRED

Further Studies on the Mechanism of Valproic Acid Acid-Induced Embryotoxicity (CFSAN)
Hart E0660900 Completed/

Cal Res/

CNPT

Role of Body Weight Changes on Mechanisms Modulating Chemical Toxicity in B6C3F1 Mice
Hart E0699801 Active/

Cal Res/

PRED

Memphis Study: Evaluation of Classically- Restricted Human Surgical Samples Received from Dept. Of Surgery, University of Tennessee, Memphis
Hass E0686501 Active/

R&D Tox/

AGNT

Verification of Methapyrilene, a Human Antihistamine and a Rat Liver Carcinogen, as an Agent that Alters Phenotypic Expression of Transformed Cells
Hass P00356 Completed/

Bio Tox/

METH

Determination of Viable, Necrotic, and Apoptotic Cells in Tumor Tissue
Heflich P00353 Completed/

Gen Tox/

METH

Rats for Training in Spontaneous Lymphocyte Mutation Frequencies
Henderson E0681000 Active/

Micro/

AGNT

The Role of Intestinal Microflora in the Metabolism of a Mammalian Metabolite of the Neurotoxin 1-methyl-4-phenyl-1,2,3,6-Tetrahydropyridine (MPTP) (CFSAN)
Hobbs (Oakridge Institute for Science and Education) E0689701 Completed/

Tech Adv

AGNT

Accumulation of Copper in Edible Muscle of Channel Catfish (Ictalurus punctatus) Following Exposure to Water Borne Copper Sulfate (CVM)
Holder X70036 Proposed

Chemistry/

METH

LC/MS Quantification of Heterocyclic Amines in Meat
Holder E0675100 Completed/

Chemistry/

AGNT

Investigation of Eight Mutagenic Heterocyclic Amines from In Vitro Studies Using Thermospray Mass Spectrometry (TSMS) (CFSAN) (ORA)
Holland S00189 Active/

Micro/

METH

Tuberculocidal Efficiency of Various Disinfectants (CDRH) (ORA)
Holson E0690501 Active/

R&D Tox/

AGNT

Neural and Functional Teratogenesis of Retinoids in the Rat

(CDER)

Holson X70005 Proposed/

R&D Tox/

KNLG

Neonatal Glucocoritcoid Exposure
Howard E0692501 Active/

Bio Tox/

CNPT

DNA Adduct Formation by Nicotine Metabolites
Jackson E0695601 Active/

R&D Tox/

CNPT

An Evaluation of Dietary Fibers for the Prevention of Mammary Cancer in Female Rats
Jackson X60008 Proposed/

R&D Tox/

PRED

An In Vitro surrogate Assay for Agents Modulating Mammary Cancer
Jackson E0685200

E0685211

Completed/

R&D Tox/

AGNT

Doxylamine: Secondary Mechanisms of Carcinogenicity in Male B6C3F1 Mice (CDER)
Jackson E0685800 Active/

R&D Tox/

CNPT

Requirements for Dietary Nucleotides and Folic Acid in Rapidly Dividing Cells: II. Effect of Partial Hepatectomy on Foci and Tumor Development
James-Gaylor E0700301 In Review/

Bio Tox/

CNPT

Nutritional Modulation of Apoptosis and Chemosensitivity: A Novel Anticancer Strategy
James-Gaylor E0696101

E0696111

Active/

Bio Tox/

AGNT

Mechanisms of Immunotoxicity and Carcinogenicity Associated with Silicone Breast Implants (CDRH) (OWH)
James-Gaylor E0687501

E0687511

E0687521

Active/

Bio Tox/

CNPT

Mechanisms of Diet-Induced DNA Damage with Methyl Donor Deficiency (CFSAN)
James-Gaylor E0689801

E0689813

Active/

Bio Tox/

CNPT

Mechanisms of Foreign-Body Carcinogenesis: The Role of Inflammation, Proliferation, and Cell Death (CDRH) (CFSAN)
Kadlubar E0694701 Active/

Mol Epi/

PRED

Role of Acetylation and N-Oxidation in Colorectal Cancer
Kadlubar E0694601 Active/

Mol Epi/

PRED

A Case-Control Study of Pancreatic Cancer and Aromatic Amines
Kadlubar X60038 Proposed/

Mol Epi/

PRED

Ovarian Cancer: Bioactivation and DNA Adducts
Khan X70032 Proposed/

Micro/

METH

DNA Finger Printing of Environmental and Clinical P. aeruginosa by PFGE
Khan E0690001 Active/

Micro/

METH

Development of a Detection Method for Tracking Genetically-Engineered Microorganisms using Polymerase Chain Reaction and DNA-DNA Hybridization Methods (CVM)
Kim E0699901 In Review/

Micro/

PRED

Biochemical and Molecular Analysis of Polycyclic Aromatic Hydrocarbon (PAH) Degradation by Bacteria
Kodell S00175 Active/

Biometry/

CNPT

Application of Biometrical Procedures for NTP Projects
Kodell X70045 Proposed/

Biometry/

METH

Trend Test for Clustered Exchangeable Binary Data
Kodell S00174 Active/

Biometry/

METH

Modification and Application of Quantitative Risk Assessment Techniques to FDA Regulated Products (CDER)(CDRH) (CFSAN) (CVM)
Kodell E0690201 Active/

Biometry/

PRED

Bioassays of Shortened Duration for Drugs: Statistical Implications (CDER)
Kodell E0689601 Active/

Biometry/

METH

Attribution of Tumor Lethality in the Absence of Cause-of-Death Information
Kodell E0683800 Completed/

Biometry/

METH

Adjusted P-values for Tests of Multiple Tumor Sites (CFSAN) (CDER)
Kodell X70044 Proposed/

Biometry/

METH

Statistical Evaluation of Mass Spec Confirmation Methods for Regulation Purposes
Kodell X70048 Proposed/

Biometry/

KNLG

A New Strategy for Detecting Carcinogenicity
Laborde S00162 Active/

R&D Tox/

METH

Teratology Training
Laborde X70055 Proposed/

R&D Tox/

AGNT

Endocrine Disruptors - Teratology Study
LaBorde E0697601 Active/

R&D Tox/

CNPT

Dose-Response of Retinoic Acid-Induced Stress Protein Synthesis and its Correlation with Developmental Toxicity in CD-1 Mice (CDRH)
Lay X70040 Proposed/

Chemistry/

KNLG

Bacterial ID Using MALDI-TOF-MS
Lay X70041 Proposed/

Chemistry/

KNLG

Identification of Bacterial Toxins by LC/MS
Lay E0678500 Active/

Chemistry/

METH

Development of FAB/MS and FAB/MS/MS Methodologies for the Analysis of Peptides (CFSAN)
Lay E0665300 Completed/

Chemistry/

METH

Development of Mass Spectral Methods for the Identification of Trace Levels of Unknown Carcinogen-Nucleoside Adducts
Leakey X00006 Proposed/

Cal Res/

CNPT

Hypothalmic-Pituitary-Adrenal Axis/Hepatic Rats
Leakey E0676600 Active/

Cal Res/

AGNT

In Vitro Metabolism of Topical Antimicrobials (CDER)
Leakey E0637100

E0637102

Active/

Cal Res/

CNPT

Profiles-Hepatic Detoxicating Enzymes
Lewis E0657500

E0657501

Active/

Cal Res/

METH

Nutrient Digestibility and Nitrogen Balance Among Fischer 344 Rats and B6C3F1 Mice Fed NIH-31 Standard and Fortified Diets
Lipe E0682900 Active/

Neuro Tox/

AGNT

Effect of Manganese on the Concentration of Amino Acids in Various Regions of the Rat Brain (CFSAN)
Littlefield P00357 Completed/

Bio Tox/

AGNT

Do Heavy Metal Ions Induce Apoptosis?
Littlefield E0684800 Active/

Bio Tox/

AGNT

The Effect of Dietary Magnesium on the Induction of Tumors, Transformation of Cells, and Leukemia Incidence
Littlefield E0686101

E0686111

Active/

Bio Tox/

CNPT

Determination and Evaluation of Toxicity, Tumor-Promoting Activity, and Synergistic Interactions Between Granulocyte-Macrophage Colony-Stimulating Factors and Agents (CBER)
Littlefield E0696701 Active/

Bio Tox/

AGNT

Investigations into the Interactive Oxidative Effects of Magnesium and Calcium with Selected Heavy Metals
Lu X70059 Proposed/

Cal Res/

AGNT

Investigation of Reproductive and Developmental Toxicity of Tamoxifen by Flow Cytometric Cell Cycle Analysis
Lu E0665900

E0665901

E0665921

Active/

Cal Res/

CNPT

Effects of Dietary Restriction on Cell Cycle Analysis in Rats and Mice
Lu E0676900 Active/

Cal Res/

CNPT

DNA Repair and Cellular Responses of Dietary Restricted Rats Exposed to Carcinogens
Lyn-Cook X00128 Proposed/

Mol Epi/

CNPT

Zinc Deficiency Pancreatic Acinar Cell In Vitro
Lyn-Cook E0673200 Completed/

Mol Epi/

CNPT

Characterization and Expression of p53 Proto-Oncogene in Dietary Restricted Rats: Biomarker for Susceptibility to Carcinogenesis
Lyn-Cook E0687801

E0687811

Active/

Gen Tox/

CNPT

Evaluation of the Effects of Dietary Antioxidants on Lymphocyte Function and Genotoxicity Induced in Young and Old Rats Exposed to DNA-damaging Agents In Vivo (CFSAN)
Lyn-Cook X40056 Proposed/

Mol Epi/

CNPT

Modulation of the MDR Gene by Caloric Restriction
Manjanatha E0695001 Active/

Gen Tox/

PRED

Molecular Analysis of In Vitro Mutations in the Transgenic Rat2 Cells Exposed to DMBA and Tamoxifen: Comparison of Mutagenesis in the Transgene lacI with the Endogenous Gene hprt (CDER) (CBER)
Manjanatha E0690601

E0690611

Active/

Gen Tox/

PRED

Quantitative and Molecular Analysis of 7,12-Dimethylbenz[a]anthracene-Induced Mutations in the Model Blue Rat: Comparison of Mutagenesis in the Transgene lacI with the Endogenous Gene hprt and Cancer Genes H-ras and P53 (CFSAN) (CDER) (CBER)
Manjanatha X70026 Proposed/

Gen Tox/

PRED

A Study of DNA Repair in the Transgene of Big Blue Rats
Medlock

Burroughs

E0689101

E0689111

Active/

R&D Tox/

KNLG

Alterations in Reproductive Tract Morphology and Biochemistry in Rats Treated Neonatally with Phytoestrogens (CFSAN)
Miller E0687401 Active/

Chemistry/

METH

Development of Devices/Methods for Determination of Food/Seafood Quality (ORA) (CFSAN)
Miller E0699701 In Review/

Chemistry/

METH

Innovative Methods for Determining Food Quality: Decomposition, Safety and/or Economic Fraud (ORA)
Miller X70039 Proposed/

Chemistry/

METH

Waste Disposal Methods for Chemsyn Contract Close Out
Mittelstaedt E0689201 Completed/

Gen Tox/

METH

PCR-DGGE and PCR-SSCP Analysis of Mutation in the HPRT Gene of Rat Lymphocytes
Morris E0674100 Completed/

Gen Tox/

CNPT

Biological Response Measurements in the Human
Morris P00341 Completed/

Neuro Tox/

METH

Use of Rats to Test New Behavioral Equipment and Related Computer Software and to Train Personnel in Their Operation
Morris X70029 Proposed/

Gen Tox/

AGNT

Molecular Analysis of Genistein Mutants
Morris E0699601 Active/

Gen Tox/

CNPT

Evaluation of the Genotoxic Potential of Genistein in Human Lympho-blastoid Cells
Morris E0691701 Completed/

Gen Tox/

AGNT

Cell Proliferation and Programmed Cell Death in Human Lymphoblastoid Cells (AHH-1 and TK6) Exposed to the Protein Cross-Linking Agents, Methyl Acetimidate and Dimethyl Adipimidate
Nawaz E0700101 In Review/

Micro/

CNPT

Purification and Characterization of Antibacterial Protein from Oysters (CFSAN)
Norris P00370 Active/

Dep Dir/

KNLG

Development of an Estrogen Knowledge Base for Research and Regulation
Parsons E0693501 Active/

Gen Tox/

METH

Development of Methods for the Biochemical Selection of Mutations
Patterson E0699201 In Review/

Neuro Tox/

PRED

Validation Study of the Physiologically-Based Pharmacokinetic (PBPK) Model for Description of low-dose, long-term Exposure of 2,4-Dichlorophenoxyacetic Acid (2,4-D) Dosimetry in the Central Nervous System (CNS) (CFSAN)
Paule E0684500 Active/

Neuro Tox/

AGNT

Preliminary Assessment of a Method for Screening Potential Neurotoxic Effects of Prenatal Alcohol Exposure using Autoradiographic Measurement of Cellular Metabolic Markers (CDER)
Paule E0682200

E0682211

Active/

Neuro Tox/

AGNT

The Effects of Chronic MPTP Administration on Complex Brain Function, Neurochemistry and Neurohistology in the Rhesus Monkey (CFSAN)
Paule E0683700 Active/

Neuro Tox/

AGNT

Effects of Chronic Methlyphenidate (Ritalin) Administration on 'Cognitive' Functions in the Rhesus Monkey (CDER)
Paule X60048 Proposed/

Neuro Tox/

AGNT

Grant Proposal to NIDA
Paule X60042 Proposed/

Neuro Tox/

PRED

Clinical Use of the NCTR Operant Test Battery (OTB)
Paule S00138 Active/

Neuro Tox/

METH

Nonhuman Primate Operant Behavior Training and Maintenance
Pipkin E0671700 Active/

Gen Tox/

CNPT

The Stress Mobility Group of Proteins as Potential Biomarkers of Caloric Restriction In Aging Rats
Pipkin E0694901

E0694911

Active/

Gen Tox/

PRED

The Effect of P53 Null Phenotype on Bleomycin-induced Stress Protein Elicitation In Vivo in Transgenic Mice (CDER) (CBER)
Poirier E0665800

E0665801

Active/

Mol Epi/

METH

Validation of In Vitro and In Vivo Transformation Assays Using Liver Cell Lines Previously Treated with Hypomethylating Carcinogens
Poirier P00368 Complete/

Mol Epi/

PRED

A Literature Review of Secondary/ Indirect Mechanisms of Tumor Development
Poirier E0667700

E0667701

Active/

Mol Epi/

CNPT

A Study to Determine If the Carcinogenic Effect of a "Methyl-Deficient" Diet on Rats Can Be Reversed by a "Methyl-Sufficient" Diet
Poirier X60001 Proposed/

Mol Epi/

CNPT

Methyl Insufficiency in Carcinogenesis
Poirier X70020 Proposed/

Mol Epi/

PRED

Abnormal DNA Methylation in Hepatocarcinogenesis
Poirier X70021 Proposed/

Mol Epi/

PRED

Predictive Assays in Hepatocarcinogenesis
Poirier E0665000 Active/

Mol Epi/

CNPT

Altered Expression of Oncogenes in Rats Fed a Methyl-Deficient Diet
Pothuluri E0690101 Active/

Micro/

METH

Microbial Degradation of Drugs and Feed Additives Used in Fish Farming (Aquaculture) (CVM)
Pothuluri X70042 Proposed/

Micro/

METH

Microbial Degradation and Fate of Oxytetracycline Used in Aquaculture
Prathibha P00363 Completed/

Mol Epi/

CNPT

Impact of Nutritional Modulation on Cell Proliferation of Human Hepatoma Cell Line (HuH 7)
Rafii X70051 Proposed/

Micro/

KNLG

Mechanism of Acid Tolerance in Foodborne Pathogens
Rafii E0695901 In Review/

Micro/

METH

Cloning and Characterization of the Genes Involved in the Metabolism of Nitro Compounds by Mycobacterium sp. Pyr-1
Rafii E0693201 Active/

Micro/

METH

Polymerase Chain Reaction Fragment Length Polymorphism (PCR-RFLP) for Analysis of the Azoreductase Gene of Anaerobic Bacteria Isolated from the Human Intestinal Tract
Rafii S00170 Active/

Micro/

RSUP

Animals for Antibody Production
Roberts P00319 Completed/

Bio Tox/

METH

Develop Methodology to Test antibody Response in Modified Sheep RBCs
Roberts E0698701 Active/

Bio Tox/

METH

Tandem Immunochemical - Analytical Methods (CVM) (ORA)
Roberts X60036 Proposed/

Bio Tox/

METH

Immunoaffinity Analysis of Oxidative Damage
Rowland X60043 Proposed/

Neuro Tox/

CNPT

Risk Factors for Attention Deficit Hyperactivity Disorder (ADHD)
Rushing X70037 Proposed/

Chemistry/

METH

Uptake and Depletion of Gentian Violet in Catfish
Sams P00365 Active/

Bio Tox/

METH

Oxidative Stress-Related DNA Damage and hprt Mutations in the Rodent Air Pouch
Scallet E0681800 Completed/

Neuro Tox/

AGNT

Characterization of the Neurobehavioral Toxicity Associated with Low Dose Exposure to Domoic Acid in the Rat (CFSAN) (ORA)
Scallet E0693001 Active/

Neuro Tox/

AGNT

Estimating Quantitative Neurotoxicity Risk from Domoic Acid Exposure (CFSAN)
Schmued X60044 Proposed/

Neuro Tox/

PRED

Development and Validation of a Neurohistochemical Test Battery
Shaddock E0662700 Active/

Gen Tox/

METH

Reliable Methodology for Cryopreservation
Shaddock E0688901 Active/

Gen Tox/

METH

Effect of Cryopreservation and Long-Term Storage of Primary Rodent Hepatocytes on I25 I-Insulin Uptake and Binding and the Regulation of Hepatic Pyruvate Kinase by Insulin and Glucagon Treatment
Shaddock X60021 Proposed/

Gen Tox/

METH

A Study of Several Hepatocarcinogens in the Rat Hepatocyte System: The Effect of AFB1, 2-AAF, Clofibrate, and Methapyrilene on Gene Expression and Induction of Stress Proteins
Sheehan P00369 Active/

R&D Tox/

KNLG

A Biologically Based dose Response Model for Estradiol Effects on Sex Determination in Turtles
Sheehan E0676800 Completed/

R&D Tox/

KNLG

Estrogen-Induced Normal and Dysplastic Uterine Growth (CDER)
Sheehan P00358 Active/

R&D Tox/

KNLG

Training in the Estrogen Developmental Toxicity Bioassay (OWH)
Sheldon E0680000

E0680011

Completed/

Cal Res/

CNPT

Development and Distribution of Optic Tract Lesions in DBA/2NNIA Mice, Restricted Versus Ad Libitum Diet
Shuttleworth P00354 Completed/

Micro/

AGNT

Microbial Degradation of Dimethylformamide
Shuttleworth E0681300 Active/

Micro/

CNPT

Investigations of the Content and Fate of PAHs in Sediments Collected Near Commercial Fishing Areas and the Effects of Bioaugmentation with a PAH Degrading Mycobacterium Sp. in Environmental Microcosms
Shuttleworth E0678700 Completed/

Micro/

PRED

Degradation of Polycyclic Aromatic Hydrocarbon by Bacteria in Continuous Culture
Shuttleworth X70033 Proposed/

Micro/

PRED

Effects of Physiochemical Factors on the Metabolic Potential of the Drug Metabolizing Fungus, Cunninghamella elegans
Siitonen X70034 Proposed/

Chemistry/

CNPT

ICP/MS and Speciation Analysis of Mn & Cr
Slikker X30029 Proposed/

Neuro Tox/

METH

Risk Assessment of Neurotoxicants
Slikker E0676100

E0676111

Completed/

Neuro Tox/

CNPT

Postnatal Ontogeny of Neurotoxicity Susceptibility to Phenylisopropylamine Serotonergic Neurotoxicants (CDER)
Slikker E0688401 Completed/

Neuro Tox/

AGNT

Developmental Neurotoxicological Assessment of Fumonisin (FB1) Toxicosis in Rats (CFSAN)
Streck X70004 Proposed/

R&D Tox/

CNPT

Retinoic Acid Receptor Expression
Streck E0697301 Active/

R&D Tox/

KNLG

Mechanism of Tamoxifen Developmental Toxicity and Neoplasia: Tamoxifen Effects on the Rat Uterine Insulin-Like Growth Factor System (CDER) (OWH)
Streck

Rajaratnam

E0689001

E0689011

Active/

R&D Tox/

CNPT

Effects of Maternal Diabetes and Insulin on Fetal Expression of Insulin-like Growth Factor and Insulin-like Growth Factor Binding Protein mRNAs (CDER)
Sutherland X70049 Proposed/

Micro/

AGNT

Methods for Detection of Beauvericin and Moniliformin
Sutherland E0692201 Active/

Micro/

AGNT

Microbial Metabolism of Fumonisin (CFSAN)
Sutherland X70050 Proposed/

Micro/

METH

Rapid and Sensitive Detection of Staphylococcus Enterotoxin Using Mass Spectrometry Techniques
Tang E0699001 Active/

Mol Epi/

PRED

The Role of Human Cytochrome CYP1B1 in Drug Metabolism and Carcinogenesis
Tang X60039 Proposed/

Mol Epi/

PRED

Role of Human CYP1B1 in Carcinogen/Drug Metabolism
Teitel E0689401

E0689411

E0689421

Active/

Mol Epi/

PRED

Chemoprotection of DNA Adducts of 2-Amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine in the

Rat

Terry E0691801 Active/

R&D Tox/

PRED

Immunohistochemical Localization of Folate in the Neural Tube at the Time of Closure (CFSAN)
Terry E0692901 Active/

R&D Tox/

PRED

Toxicant Effects on Neural Cell Adhesion Molecule and N-Cadherin during Mouse Neural Tube Closure (CFSAN)
Thompson E0677400 Completed/

Chemistry/

METH

Development of Methods for Analysis and Confirmation of Non-Volatile Nitrosamines and other N-Nitroso Compounds in Cosmetics and their Raw Materials (CFSAN)
Thompson E0679700 Completed/

Chemistry/

METH

Single Residue Method Evaluation for Azocyclotin in Citrus Fruits and Vegetables (CFSAN)
Thompson E0679800 Completed/

Chemistry/

METH

Single Residue Method Evaluation for Dinoseb In Citrus, Fruits and Vegetables (CFSAN)
Thompson E0679900 Completed/

Chemistry/

METH

Single Residue Method Evaluation for Bitertanol Residues in Fruits and Vegetables (CFSAN)
Thompson E0677300 Completed/

Chemistry/

METH

Single Residue Method Evaluation for Fenbutatin Oxide in Apples, Oranges, and Cucumbers (CFSAN)
Thompson E0672900 Active/

Chemistry/

METH

Development of Method(s) for Analysis of Cadmium and Lead in Calcium Supplements by Graphite Furnace Atomic Absorption Spectrophotometry (CFSAN) (ORA)
Thompson X60010 Proposed/

Chemistry/

PRED

Metal Speciation in Foods and Food Packaging
Thompson S00158 Active/

Chemistry/

METH

FDA Scientific Exchange for Methods Development (CFSAN) (ORA)
Thompson E0677100 Completed/

Chemistry/

METH

Development of Method(s) for Analysis of Fumonisin in Corn-Based Food/Feeds by HPLC and Fluorescence Detection (CFSAN)
Tolleson X70014 Proposed/

Bio Tox/

METH

Age-Related Predisposition to Carcinogens
Tolleson X70013 Proposed/

Bio Tox/

METH

Spingolipids and Vascular Damage
Turturro P00338 Active/

Cal Res/

METH

Training for Special Employment Program (Foreign National) in the PCR
Turturro X40057 Proposed/

Cal Res/

CNPT

Effects of Food Restriction on Risk

Assessment

Turturro X70053 Proposed/

Cal Res/

AGNT

Model Toxic Response Using Neural Networks
Valentine, C. E0685600

E0685611

Completed/

Gen Tox/

PRED

Metabolism of Carbamazepine by Human Lymphoblastoid Cells Expressing Human CYP450s
Valentine E0700201 In Review/

Gen Tox/

PRED

The Development of Transgenic Mice Harboring Bacteriophage NCTR Research Plan

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