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| Cooperating Organization:
American Institute for Cancer Research |
Project
Number |
Principal/
Co-Principal
Investigator(s) |
Status/
Res. Area/
GOAL |
Title |
Objective |
E0260101
E0260111
E0260112 |
DjuricWayne State University
Hart
Lewis
Lu |
Active/
Cal Res/
CNPT |
Modulation of Oxidative DNA Damage in Rats by
Diet |
1. To examine the relationships between the
level of oxidative DNA damage and fat intake. 2. To examine the relationship between the
level of oxidative DNA damage and energy intake. |
E0260201
E0260211
E0260221 |
GandyUniversity of Arkansas for Medical
Sciences
Leakey
Manjgaladse
Seng |
Active/
Cal Res/
CNPT |
Effect of Caloric Restriction on Rat Testicular
Tumor Formation |
All of the aims of this proposal are directed
towards understanding the role of dietary components (i.e., caloric restriction) in
influencing the ultimate susceptibility of the male reproductive tract to chemical insult.
|
E0260301
E0260311
E0260313
E0260321
E0260331 |
Wolff
Kaput
Visek |
Active/
Bio Tox/
CNPT |
Caloric Restriction and Gene Expression in
Agouti Mice (CDER) |
The total amount of fat and calories we
consume in our diet is highly correlated with the occurrence of cancer in North America
and other highly developed nations. The studies proposed will help us learn how calories
modify the development of cancer in mice and the mechanism underlying cancer development
in humans. |
| Cooperating Organization: Electric Power
Research Institute |
Project
Number |
Principal/
Co-Principal
Investigator(s) |
Status/
Res. Area/
GOAL |
Title |
Objective |
| E0672201 |
Beland
Culp
Dooley |
Active/
Bio Tox/
CNPT |
Twenty-One Day Diet Rangefinding Study |
1. Develop methods for mixing coal tar residues in NIH-31
diets at various concentrations. 2. Determine the palatability of a representative coal
tar mixture that will be used in a subsequent chronic bioassay. 3. Develop methods to
quantify DNA adducts by 32P-postlabeling. |
| E0672202 |
Beland
Culp
Dooley
Fullerton
Kaderlik |
Active/
Bio Tox/
CNPT |
Chronic Bioassay of Two Composite Samples From Selected
Manufactured Gas Plant Waste Sites |
To determine the risk associated with exposure to coal tar
mixtures obtained from manufactured gas plant waste sites. |
E0672203
E0672223
E0672231
E0672233 |
Culp
Beland
Dooley |
Active/
Bio Tox/
CNPT |
DNA Adduct and Cell Replication Analyses of Mice Treated
w/Two Composite Samples from Selected Manufactured Gas Plant Waste Sites |
To determine the relationships among tumor induction, DNA
adduct formation, and cell replication activity in female B6C3F1 mice resulting from
exposure to coal tar mixtures obtained from manufactured gas plant waste sites. |
| E0675200 |
Cerniglia
|
Active/
Micro/
CNPT |
The Role of Human Intestinal Microflora in The Metabolism
of Compounds in Gas Manufacturing Plant Residues |
1. To determine the effect of compounds in gas
manufacturing plant residues on the microbial activity and ecology of human intestinal
microflora. 2. To determine the role of human intestinal microflora in metabolizing
compounds contained in gas manufacturing plant residues. |
| Cooperating Organization: Procter &
Gamble |
Project
Number |
Principal/
Co-Principal
Investigator(s) |
Status/
Res. Area/
GOAL |
Title |
Objective |
| E0270001 |
Jackson
Detilleux |
Active/
R&D Tox/
CNPT |
Role of Hepatotoxicity in the Induction of Liver Tumors in
B6C3F1 Mice Treated with Doxylamine, Pyrilamine, and Triprolidine (CDER) |
The hypothesis to be tested is that liver tumors resulting
from administration of doxylamine to mice is an indirect result of hepatotoxicity and cell
proliferation induced by doxylamine. The objective is to test the hypothesis by
re-examining liver tissues of male mice from previous NCTR studies on doxylamine,
triprolidine, and pyrilamine for hepatotoxicity and cell proliferation and to correlate
this with liver tumor incidence at each dose level and length of exposure.
|
| Cooperating Organization: Gentest
Corporation |
| X70054 |
Leakey
Seng |
Proposed/
Cal Res/
PRED |
Predictive Systems for Human Drug Metabolism |
Determine whether age, disease, diet and/or body mass
influence expression of hepatic drug metabolizing enzymes in monkeys and humans; To assess
what influence altered drug metabolizing enzyme expression with have on drug efficacy and
toxicity. |
|
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