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CVM Profile - James O. Peggins, III

James O. Peggins, III

Chemist

Ph.D. in Pharmacology and Toxicology,
University of Maryland at Baltimore, 1996
B.S. Distributed Sciences,
The American University, Washington, DC, 1981
jpeggins@cvm.fda.gov
Phone: 301-827-8092
Fax: 301-827-8170

Research interests include drug metabolism, pharmacokinetics and analytical methods development. Current projects involve the study of comparative pharmacokinetics of fenbendazole in dairy and beef cattle and the investigation of the use of tissue-fluid correlation data to develop mathematical models for estimating drug residue levels in edible tissues.

Selected Bibliography:

  1. Q. Li, R.P. Brueckner, J.O. Peggins, K.M. Trotman and T.G. Brewer. Arteether toxicokinetics and pharmacokinetics in rats after 25 mg/kg/day single and multiple doses. Eur. J. Drug Metab. Pharmacokinet., 24(3):213-223, 1999.

  2. Q. Li, J.O. Peggins, A.J. Lin, K.J. Masonic, K.M. Trotman and T.G. Brewer. Pharmacology and toxicology of artelinic acid: preclinical investigations on pharmacokinetics, metabolism, protein and red blood cell binding, and acute and anorectic toxicities. Trans. R. Soc. Trop. Med. Hyg. May-Jun;92(3):332-40,1998.

  3. O.R. Idowu, J.M. Grace, K.U. Leo, T.G. Brewer and J.O. Peggins. Rapid derivatization of alcohols with carboxylic-sulphonic mixed anhydrides for HPLC-uv/fluorescence analysis. Application to the detection of dihydroqinghaosu (DQHS) and its metabolites in biological samples. J. Liq. Chrom. & Rel. Technol. 20(10): 1553-1577, 1997.

  4. M.T. Marino, J.O. Peggins and T.G. Brewer. High-performance liquid chromatographic method for the determination of a candidate 8-aminoquinoline antimalarial drug (WR242511) using oxidative electrochemical detection. J. of Chromatogr. 616: 338-343, 1993.

  5. J.O. Peggins, T.F. McMahon, M. Weiner, and L. Lesko. Effects of age on theophylline metabolism in vivo and in vitro in Mongolian Gerbils. Mech. of Ageing Develop. 66: 173-186, 1992.

updated October 31, 2000 at 9:10 AM ET


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