Table of Contents

OR Page
DAR Page
Russell A. Frobish
Dorothy E. Farrell
Joesph C. Kawalek
Michael J. Myers

Dorothy E. Farrell

Microbiologist

B.S. from the College of Agriculture and Life Sciences,
University of Maryland, College Park, 1978
Major: Microbiology
Graduate Courses: Pharmacology, Toxicology, and Immunology,
(19 credits)
dfarrell@cvm.fda.gov
Phone: 301-827-8137
Fax: 301-827-8127

I have worked, for the Federal Government, in many settings, both while I was a student at the University of Maryland, and thereafter. Initially, while a student in Microbiology at Maryland, I worked at the USDA in a ruminant laboratory, doing anaerobic colony propagation, in glass roller tubes, of samples taken from test animals, as well as HPLC analysis of samples. Thereafter, and also while still a student at Maryland, I received a position with the Howard County Government, at the Little Patuxent Water Quality Management Center, to work in their water quality testing laboratory examining, both chemically and microbiologically, the quality of the effluent waters released from the facility.

My FDA career began, at the Bureau of Drugs, in a reproductive research laboratory where the focus was the study of the effect of Cholera Toxin and variations in light and dark on the pineal gland, Circadian Rhythms and the reproductive cycle in hamsters. My next employment, also with the Bureau of Drugs, was in an antibiotic testing laboratory doing plate assay and turbidimetric analysis on manufacturers’ lots of anitibiotics, using bacterial sensitivity as an endpoint. Next, I worked at the Center for Biologics Evaluation and Research, in a Virology laboratory, doing viral plaque assays, primarily on Pediatric, Enteric and Neurologic disease viruses. Much of my work centered on the collaborative immunization efforts of the FDA with CDC, the World Health Organization and the Pan American Health Organization. The efforts to end the threat of childhood diseases in this country and in "third world" countries, where many childhood illnesses cause death, was most gratifying. My most recent employment is at the Center for Veterinary Medicine, where I act as a support scientist, involved in the research programs of a Pharmacologist. The focus of this research is primarily immunotoxicology in large farm animals. My function is in support of the laboratory programs, utilizing cytokine assays, PCR, ELISA, PAGE, and Western Blots, to measure the immunotoxic effect of various drugs, in test animals.

Selected Bibliography:

1. M.J. Myers, D.E. Farrell, J.D. Baker, C.V. Cope, C.M. Evock-Clover and N.C. Steele. 1999. Challenge Differentially Affects Cytokine Production and Metabolic Status of Growing and Finishing Swine. Domestic Animal Endocrinology. 17:000-000.

2. M.J. Myers, D.E. Farrell, K.D. Howard and J.C. Kawalek. 1998. Identification and Population Dynamics of Multiple Constituative and Inducible Swine Cytochrome P450 Enzymes. Drug Metabolism and Disposition. In press.

3. M.J. Myers, D.E. Farrell, C.M. Evock-Clover, M.W. Mc Donald, N.C. Steele. 1997. Effect of Recombinant Growth Hormone and Chromium Picolinate on Cytokine Production and Growth Performance in Swine. Am J Vet Res. 58:594-600.

4. M.J. Myers, D.E. Farrell, M. Henderson. 1995. Modulation in vitro of Bovine Polymorphonuclear Leukocytes and Peripheral Blood Mononuclear Cells by Oxytetracycline. Am J Vet Res. 56:1007-1011.

5. L.E. Markowitz, P. Albrecht, W.A. Orenstein, S.M. Lett, T.J. Pugliese, D.E. Farrell. 1992. Persistence of Measles Antibody After Revaccination. Journal of Infectious Diseases. 166:205-208.
   

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