Summary of Case Reports (II)

Analysis of 61 single reports with fenfluramine-phentermine use received through August 29, 1997

Mean Range

% Female 97

Age 44.9 22-67

Weight (lb) 200 129-350

Fen dose (mg/d) 56 10-120

Duration (mos) 11.9 2-39

(does not include 24 cases from Mayo article)

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2. As of late August 29, 1997, 61 reports (excluding the 24 cases from the Mayo article) of valvular regurgitation in patients treated with the combination of fenfluramine-phentermine had been analyzed in aggregate. Nearly all reports were in women; the mean age was about 45.