Slide 13 of 16

10. We used data from the CARDIA study as a reference in order to estimate the relative risk of significant valvular regurgitation. The estimates for each site and the overall pooled estimate are shown. The estimates ranged from 13-18, with a pooled estimate of 14.6 (12.2-17.4). Compared to the expected rate in the general population, patients treated with fenfluramine-phentermine or dexfenfluramine +/- phentermine had about a 15-fold increased risk of having valvular dysfunction.