Slide 11 of 16

8. The absolute risk of valvular dysfunction meeting our definition was consistent across the five survey sites, ranging from 29% to 38%. The estimates of risk were homogeneous across sites, permitting pooling of data, for an overall estimate of absolute risk of .317 (31.7%). From Dr. Khan's site, we also had data on 20 echocardiograms performed on subjects treated with dexfenfluramine, either with or without phentermine. The absolute risk in this group was .300 (30%).