Slide 10 of 16

7. In total, 271 subjects treated with fenfluramine-phentermine in combination were identified for this analysis. There were 86 cases (32%) meeting the "research" definition. Aortic regurgitation of mild or greater severity was found in 76 (28%) and mitral regurgitation of moderate or greater severity was found in 21 (8%). Eleven subjects (4%) had regurgitation meeting the case definition at both the aortic and mitral valves.