Ventricular Arrhythmia (Torsades de Pointes) Occurring in Association with Terfenadine Use
Monahan BP et al. JAMA 1990;264:2788–2790
39 y.o. female with 2-day Hx of intermittent syncope
Rx with terfenadine 60 mg bid and cefaclor 250 mg tid ? 10 d
Self-medicated with ketoconazole 200 mg bid for vaginal candidiasis
Palpitations, syncope, torsades de pointes (QTc 655 msec)