Cytochrome P450 2C19

• Absent in 20–30% of Asians, 3–5% Caucasians

• Primary metabolism of:

  • Diazepam
  • Phenytoin
  • Omeprazole

• Inhibited by:

  • Omeprazole
  • Isoniazid
  • Ketoconazole

Previous slide

Next slide

Back to first slide

View graphic version