Why Are There So Many ADRs?

Schappert SM. Nat. Center Health Statistics. 1999, Series 13 No. 143

National Association of Chain Drug Stores. 2001

Jacubeit T et al. Agents Actions Suppl 1990;29:117–125

• Two-thirds of patient visits result ina prescription

• 2.8 BILLION outpatient prescriptions(10 per person in the United States) filledin 2000

• ADRs increase exponentially with4 or more medications

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