Table of Contents
PPT Slide
PPT Slide
Learning Objectives
Learning Module
Torsades de Pointes
Ventricular Arrhythmia (Torsades de Pointes) Occurring in Association with Terfenadine Use
PPT Slide
Why Learn about Adverse Drug Reactions (ADR)?
Costs Associated with ADRs
Why Are There So Many ADRs?
Characterization of New Drug’s Safety Profile Before Marketing
Misconceptions about ADR Reporting
Drugs Removed from or Restricted in the U.S. Market Because of Drug Interactions
Primary Worries in Primary Care: 1008 Patients
Contribution of Drug Interactions to the Overall Burden of Preventable ADRs
Systems Interventions and Their Limitations
Prescribing to Avoid Adverse Drug Reactions
Interactions Before Administration
In the GI Tract
Interactions in the Serum
Spectrum of Consequences of Drug Metabolism
Microsomal Enzymes
Phases of Drug Metabolism
Drug Interactions Due to Hepatic Metabolism
Phase I Drug Oxidation
Cytochrome P450 Isoforms
Cytochrome P450 Nomenclature, e.g. for CYP2D6
CYP450
Polymorphic Distribution
Cytochrome P450 3A
CYP3A Inhibitors
CYP3A Inducers
Cytochrome P450 2D6
Cytochrome P450 2C9
Cytochrome P450 2C19
Cytochrome P450 1A2
www.drug-interactions.com
Drug-Disease Interactions
Drug-Food Interactions
PPT Slide
Drug-Herbal Interactions
PPT Slide
PPT Slide
Drug-Drug Interactions: A Stepwise Approach
A Good Medication History: AVOID Mistakes
This completes the ADR learning module. Please check the following web sites for more learning tools.
Clinical Pharmacology: The Science of Pharmacology and Therapeutics
Acknowledgements
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