Drug 14d. Replicate Design Trt 1=3: Test Trt 2=4: Reference Component #4. OBS SEQ SUBJ PER TRT AUCT AUCI CMAX 1 2 1 2 1 63.540 73.080 2.821 2 2 1 1 2 79.974 92.539 2.817 3 2 1 3 3 76.035 84.942 5.924 4 2 1 4 4 76.797 96.330 3.130 5 2 2 2 1 85.559 102.833 3.242 6 2 2 1 2 94.987 101.515 3.766 7 2 2 3 3 111.017 136.837 3.696 8 2 2 4 4 113.824 120.802 3.917 9 1 3 1 1 77.747 90.538 3.188 10 1 3 2 2 98.749 112.067 3.753 11 1 3 4 3 95.649 107.219 3.825 12 1 3 3 4 91.482 108.572 3.527 13 2 4 2 1 125.381 . 3.993 14 2 4 1 2 151.293 160.323 6.732 15 2 4 3 3 157.797 179.611 4.973 16 2 4 4 4 156.869 . 5.828 17 2 5 2 1 59.230 65.228 2.462 18 2 5 1 2 65.873 75.470 3.524 19 2 5 3 3 62.047 71.616 2.459 20 2 5 4 4 57.952 67.093 2.766 21 1 6 1 1 134.985 145.667 4.062 22 1 6 2 2 175.281 180.560 5.530 23 1 6 4 3 180.198 188.049 5.779 24 1 6 3 4 162.487 172.673 5.428 25 2 7 2 1 110.886 119.209 3.910 26 2 7 1 2 132.262 152.584 4.016 27 2 7 3 3 112.731 122.080 3.577 28 2 7 4 4 139.338 148.813 4.141 29 1 8 1 1 86.085 103.095 3.238 30 1 8 2 2 93.792 102.012 4.526 31 1 8 4 3 109.604 114.004 3.882 32 1 8 3 4 76.462 82.848 3.127 33 1 9 1 1 89.831 103.614 3.609 34 1 9 2 2 97.558 102.134 4.062 35 1 9 4 3 128.601 136.724 4.420 36 1 9 3 4 113.831 118.135 4.626 37 1 10 1 1 92.706 107.494 2.329 38 1 10 2 2 104.397 111.731 2.528 39 1 10 4 3 115.352 122.122 2.672 40 1 10 3 4 90.154 98.301 2.504 41 1 11 1 1 134.164 142.147 4.314 42 1 11 2 2 149.325 159.648 4.145 43 1 11 4 3 144.045 154.623 4.497 44 1 11 3 4 174.023 189.843 4.508 45 1 12 1 1 132.388 137.405 4.801 46 1 12 2 2 124.941 144.750 4.925 47 1 12 4 3 113.963 124.001 4.365 48 1 12 3 4 140.783 189.856 5.119 49 1 13 1 1 160.187 168.787 5.029 50 1 13 2 2 114.670 134.052 4.646 51 1 13 4 3 131.170 136.042 4.803 52 1 13 3 4 112.080 128.539 4.993 53 2 16 2 1 84.529 90.973 3.170 54 2 16 1 2 81.848 89.176 3.620 55 2 16 3 3 70.713 84.641 2.650 56 2 16 4 4 96.168 104.024 2.826 57 1 17 1 1 64.356 73.575 2.996 58 1 17 2 2 85.676 91.947 3.585 59 1 17 4 3 88.060 95.845 3.204 60 1 17 3 4 93.719 . 3.206 61 1 18 1 1 122.123 128.442 5.988 62 1 18 2 2 115.745 122.934 4.272 63 1 18 4 3 112.087 129.725 4.871 64 1 18 3 4 115.092 141.513 4.227 65 1 19 1 1 130.310 136.582 4.118 66 1 19 2 2 129.767 135.168 4.325 67 1 19 4 3 123.811 129.944 3.980 68 1 19 3 4 143.930 153.162 4.134 69 2 20 2 1 80.047 92.017 3.391 70 2 20 1 2 92.646 . 3.338 71 2 20 3 3 102.198 106.695 3.951 72 2 20 4 4 107.932 113.854 4.685 73 1 21 1 1 83.237 88.599 3.270 74 1 21 2 2 87.074 93.336 3.732 75 1 21 4 3 93.118 108.014 3.732 76 1 21 3 4 53.436 63.908 3.108 77 2 22 2 1 103.364 118.747 3.734 78 2 22 1 2 79.686 121.986 2.534 79 2 22 3 3 154.820 . 3.735 80 2 22 4 4 88.829 97.133 3.064 81 2 23 2 1 52.563 81.710 2.522 82 2 23 1 2 85.322 92.004 3.019 83 2 23 3 3 69.693 80.883 2.505 84 2 23 4 4 78.976 99.865 3.051 85 1 24 1 1 110.909 116.928 3.745 86 1 24 2 2 133.674 139.980 4.565 87 1 24 4 3 106.017 115.969 3.802 88 1 24 3 4 156.077 162.445 4.727 89 2 25 2 1 145.753 157.347 3.918 90 2 25 1 2 130.850 137.701 4.177 91 2 25 3 3 117.108 125.864 3.652 92 2 25 4 4 146.576 152.147 4.051 93 1 26 1 1 141.722 148.999 4.569 94 1 26 2 2 162.125 169.518 5.588 95 1 26 4 3 109.792 . 5.107 96 1 26 3 4 141.155 146.055 4.773 97 2 27 2 1 139.622 146.413 3.878 98 2 27 1 2 130.825 137.123 4.251 99 2 27 3 3 134.981 146.518 4.183 100 2 27 4 4 152.731 164.135 4.177 101 2 28 2 1 80.187 85.241 2.759 102 2 28 1 2 89.720 96.092 3.183 103 2 28 3 3 71.705 77.282 2.369 104 2 28 4 4 63.259 84.393 2.444 105 1 29 1 1 91.860 104.245 3.756 106 1 29 2 2 107.060 124.644 3.617 107 1 29 4 3 88.360 98.571 3.800 108 1 29 3 4 92.580 104.414 3.991 109 2 30 2 1 64.586 68.064 2.798 110 2 30 1 2 69.200 73.638 3.847 111 2 30 3 3 78.305 86.222 3.516 112 2 30 4 4 70.455 74.437 3.225 113 2 31 2 1 109.280 116.134 3.538 114 2 31 1 2 100.268 106.959 3.413 115 2 31 3 3 72.499 83.384 3.166 116 2 31 4 4 85.272 91.145 3.128 117 1 32 1 1 131.180 137.045 3.205 118 1 32 2 2 143.854 156.130 3.398 119 1 32 4 3 136.456 144.039 3.508 120 1 32 3 4 122.426 132.463 3.025 121 2 33 2 1 107.915 126.622 4.248 122 2 33 1 2 95.478 107.873 3.815 123 2 33 3 3 125.616 132.181 4.189 124 2 33 4 4 162.222 168.900 5.112 125 1 34 1 1 77.759 86.173 2.133 126 1 34 2 2 101.659 110.590 2.711 127 1 34 4 3 176.387 193.919 3.040 128 1 34 3 4 84.444 90.995 2.645 129 2 35 2 1 82.474 92.012 3.253 130 2 35 1 2 76.650 84.048 3.027 131 2 35 3 3 85.445 94.061 3.501 132 2 35 4 4 80.991 90.594 3.197 133 2 36 2 1 88.902 99.744 2.857 134 2 36 1 2 70.157 78.304 2.879 135 2 36 3 3 119.471 133.516 3.782 136 2 36 4 4 80.492 87.253 3.636 137 1 37 1 1 117.589 122.531 4.334 138 1 37 2 2 151.362 158.108 5.246 139 1 37 4 3 121.757 139.854 4.553 140 1 37 3 4 111.687 116.313 4.345 141 2 38 2 1 51.369 60.565 2.551 142 2 38 1 2 50.094 56.531 2.671 143 2 38 3 3 61.997 66.757 2.882 144 2 38 4 4 61.145 65.053 3.108 145 2 39 2 1 137.308 143.413 4.469 146 2 39 1 2 128.767 149.026 4.893 147 2 39 3 3 153.606 171.309 5.065 148 2 39 4 4 129.458 149.917 4.593 149 2 40 2 1 131.861 141.870 3.974 150 2 40 1 2 122.456 130.080 3.602 151 2 40 3 3 154.595 167.619 3.999 152 2 40 4 4 123.368 131.518 4.640