DRUG #1 TRT 1= Test TRT 2= Reference /* DRUG 1 - REPLICATE DESIGN - AABB BBAA BAAB ABBA */ input subj trt rep per cmax tmax kel thalf auc auci seq grp; 1 1 1 I 6.29 0.50 0.381 1.82 13.00 13.40 1 1 4 1 1 I 2.86 0.50 0.137 5.05 4.62 5.58 4 1 5 1 1 I 1.28 1.00 0.389 1.78 3.77 4.10 1 1 7 1 1 I 8.18 0.75 0.193 3.60 20.00 21.50 4 1 9 1 1 I 8.99 0.75 0.142 4.87 15.60 16.50 4 1 12 1 1 I 1.22 0.75 0.464 1.49 4.90 5.36 1 1 15 1 1 I 7.87 0.75 0.283 2.45 15.80 16.50 1 1 16 1 1 I . . . . . . 4 1 17 1 1 I 3.64 0.75 0.317 2.18 10.30 10.70 4 1 19 1 1 I 3.76 0.75 0.270 2.57 11.50 12.00 1 1 23 1 1 I 16.20 0.75 0.320 2.16 44.30 45.20 4 1 24 1 1 I 12.70 0.75 0.170 4.08 22.50 24.00 1 1 26 1 1 I 1.60 1.50 0.266 2.61 5.35 7.73 1 1 28 1 1 I 1.56 0.75 0.284 2.44 5.10 5.65 4 1 30 1 1 I 1.24 0.75 0.313 2.22 3.05 3.77 1 1 34 1 1 I 1.24 0.75 0.429 1.62 3.43 3.73 4 1 36 1 1 I 2.71 0.75 0.313 2.22 8.34 8.81 1 1 38 1 1 I 1.28 0.50 0.035 20.00 3.65 16.10 1 1 39 1 1 I 2.36 0.75 0.379 1.83 6.72 7.26 4 2 932 1 1 I 2.57 0.75 0.312 2.22 10.60 11.00 4 2 2 2 1 I 7.71 2.00 0.250 2.78 23.00 23.50 2 1 3 2 1 I 10.90 4.00 0.199 3.49 63.10 63.70 3 1 10 2 1 I 1.38 1.00 0.189 3.68 3.62 4.74 3 1 11 2 1 I 3.37 1.00 0.330 2.10 13.40 13.80 2 1 13 2 1 I 17.50 0.75 0.329 2.11 33.70 34.20 2 1 14 2 1 I 4.01 1.00 0.429 1.62 10.20 10.50 3 1 18 2 1 I 5.24 2.50 0.321 2.16 22.40 22.90 2 1 20 2 1 I 2.18 0.50 0.309 2.25 6.26 6.65 3 1 22 2 1 I 4.49 0.50 0.258 2.68 7.98 8.49 2 1 25 2 1 I 1.74 0.75 0.354 1.96 8.34 9.89 3 1 27 2 1 I 1.26 0.75 0.286 2.42 4.18 4.64 2 1 29 2 1 I 2.29 2.00 0.343 2.02 7.88 8.18 3 1 31 2 1 I 1.54 0.50 0.113 6.16 5.35 6.29 2 1 33 2 1 I 2.89 0.75 0.521 1.33 2.63 3.49 2 1 35 2 1 I 1.35 1.00 0.257 2.70 5.71 6.24 3 1 37 2 1 I 4.72 0.75 0.280 2.48 12.30 12.80 2 1 40 2 1 I 5.06 0.75 0.282 2.46 19.30 19.90 3 2 906 2 1 I 1.94 1.00 0.166 4.17 6.55 7.26 3 3 908 2 1 I 3.73 0.75 0.264 2.63 8.68 9.25 2 2 921 2 1 I 4.85 0.50 0.277 2.50 12.90 13.40 3 3 1 1 2 II 6.45 0.50 0.309 2.24 16.50 16.90 1 1 3 1 1 II 2.91 2.50 0.484 1.43 8.11 8.40 3 1 5 1 2 II 3.17 0.75 0.290 2.39 6.00 6.49 1 1 10 1 1 II 1.50 2.50 0.376 1.84 5.66 6.21 3 1 12 1 2 II 1.97 0.50 0.287 2.42 4.83 6.05 1 1 14 1 1 II 2.15 0.75 0.394 1.76 6.78 7.04 3 1 15 1 2 II 11.20 1.00 0.275 2.52 30.70 31.40 1 1 19 1 2 II 4.92 0.50 0.248 2.79 10.80 11.30 1 1 20 1 1 II 2.88 0.75 0.345 2.01 8.29 8.69 3 1 24 1 2 II 32.80 1.00 0.121 5.73 60.20 61.60 1 1 25 1 1 II 3.61 0.50 0.310 2.24 9.63 11.40 3 1 26 1 2 II 1.96 0.50 0.350 1.98 5.09 6.55 1 1 29 1 1 II 1.61 2.50 0.478 1.45 6.53 6.83 3 1 30 1 2 II 1.51 0.75 0.393 1.76 5.120 5.63 1 1 35 1 1 II 2.41 0.75 0.352 1.97 8.58 9.08 3 1 36 1 2 II 2.99 0.50 0.390 1.78 9.12 9.51 1 1 38 1 2 II 3.09 1.00 0.059 11.80 5.63 14.30 1 1 40 1 1 II 8.13 1.00 0.192 3.61 20.40 21.50 3 2 906 1 1 II 2.66 0.50 0.308 2.25 7.11 7.45 3 3 921 1 1 II 7.30 0.50 0.273 2.53 14.70 15.20 3 3 2 2 2 II 11.400 1.50 0.278 2.50 33.300 34.00 2 1 4 2 1 II 2.860 0.75 0.149 4.66 6.150 6.83 4 1 7 2 1 II 13.600 0.50 0.319 2.17 28.600 29.50 4 1 9 2 1 II 4.850 0.50 0.308 2.25 8.950 9.42 4 1 11 2 2 II 5.640 0.50 0.280 2.48 13.100 13.70 2 1 13 2 2 II 11.400 1.00 0.329 2.10 28.500 29.20 2 1 16 2 1 II . . . . . . 4 1 17 2 1 II 3.210 0.75 0.313 2.21 11.500 11.90 4 1 18 2 2 II 9.520 0.50 0.280 2.47 25.200 25.80 2 1 22 2 2 II 1.640 0.75 0.465 1.49 4.540 4.78 2 1 23 2 1 II 17.000 0.50 0.277 2.50 35.000 36.10 4 1 27 2 2 II 4.160 0.50 0.288 2.40 10.200 10.70 2 1 28 2 1 II 2.960 0.50 0.313 2.21 7.080 7.41 4 1 31 2 2 II 1.460 0.75 0.209 3.31 5.790 6.28 2 1 33 2 2 II 1.170 0.50 . . 0.829 . 2 1 34 2 1 II 2.430 0.75 0.394 1.76 6.910 7.32 4 1 37 2 2 II 7.230 0.50 0.262 2.64 14.600 15.10 2 1 39 2 1 II 4.890 0.75 0.367 1.89 11.600 12.00 4 2 908 2 2 II 2.690 0.50 0.318 2.18 6.480 7.12 2 2 932 2 1 II 4.980 0.50 0.479 1.45 9.090 9.56 4 2 2 1 1 III 8.310 1.00 0.274 2.53 27.300 27.90 2 1 3 1 2 III 2.740 2.50 0.359 1.93 9.280 9.67 3 1 10 1 2 III 1.500 1.00 0.452 1.53 4.560 4.92 3 1 11 1 1 III 7.370 0.75 0.322 2.15 17.400 17.70 2 1 13 1 1 III 21.000 1.00 0.310 2.24 39.200 40.10 2 1 14 1 2 III 1.760 2.00 0.285 2.43 5.340 5.86 3 1 18 1 1 III 12.200 0.75 0.274 2.53 31.600 32.50 2 1 20 1 2 III 3.960 0.50 0.343 2.02 9.310 9.63 3 1 22 1 1 III 2.670 0.75 0.420 1.65 6.170 6.53 2 1 25 1 2 III 1.860 0.75 0.293 2.36 5.760 7.15 3 1 27 1 1 III 3.950 0.50 0.283 2.45 8.950 9.31 2 1 29 1 2 III 1.050 3.00 0.415 1.67 3.700 3.99 3 1 31 1 1 III 1.560 1.00 0.287 2.42 7.410 8.05 2 1 33 1 1 III 0.715 0.50 0.018 38.20 0.818 37.60 2 1 35 1 2 III 1.820 3.00 0.218 3.17 8.480 9.08 3 1 37 1 1 III 6.470 0.50 0.304 2.28 15.600 16.10 2 1 40 1 2 III 6.840 0.75 0.333 2.08 20.600 21.30 3 2 906 1 2 III 1.900 0.75 0.235 2.96 5.410 5.84 3 3 908 1 1 III 5.550 0.75 0.331 2.10 11.900 12.30 2 2 921 1 2 III 6.230 0.50 0.279 2.48 13.600 14.10 3 3 1 2 1 III 10.200 0.50 0.326 2.13 16.200 16.60 1 1 4 2 2 III 3.150 0.75 0.389 1.78 6.780 7.12 4 1 5 2 1 III 2.470 0.75 0.245 2.83 6.900 7.46 1 1 7 2 2 III 16.200 0.50 0.326 2.12 26.100 26.70 4 1 9 2 2 III 7.430 0.75 0.248 2.80 17.600 18.00 4 1 12 2 1 III 1.900 0.50 0.024 28.50 4.130 23.20 1 1 15 2 1 III 9.610 0.75 0.265 2.61 20.500 21.00 1 1 16 2 2 III . . . . . . 4 1 17 2 2 III 3.320 0.50 0.292 2.38 9.580 9.94 4 1 19 2 1 III 10.100 0.50 0.219 3.16 18.300 19.20 1 1 23 2 2 III 5.540 0.50 0.283 2.45 20.300 21.00 4 1 24 2 1 III 14.300 0.75 0.196 3.54 31.500 32.90 1 1 26 2 1 III 4.170 0.50 0.216 3.21 5.330 8.67 1 1 28 2 2 III 3.280 0.75 0.363 1.91 9.670 10.00 4 1 30 2 1 III 0.472 1.00 0.077 8.95 2.290 5.18 1 1 34 2 2 III 2.830 0.75 0.378 1.84 7.660 8.24 4 1 36 2 1 III 2.090 0.50 0.365 1.90 6.900 7.22 1 1 38 2 1 III 3.670 0.50 0.118 5.87 8.810 14.30 1 1 39 2 2 III 3.280 0.75 0.379 1.83 7.380 7.85 4 2 932 2 2 III 7.390 0.50 0.226 3.07 13.700 14.30 4 2 2 1 2 IV 14.200 3.00 0.131 5.28 58.600 59.50 2 1 4 1 2 IV 2.810 0.50 0.242 2.87 5.880 6.72 4 1 7 1 2 IV 5.810 0.75 0.333 2.08 17.400 17.80 4 1 9 1 2 IV 4.420 0.75 0.236 2.93 14.100 14.50 4 1 11 1 2 IV 9.100 0.75 0.324 2.14 21.500 21.90 2 1 13 1 2 IV 22.100 0.75 0.260 2.67 32.800 33.70 2 1 16 1 2 IV . . . . . . 4 1 17 1 2 IV 4.540 0.75 0.313 2.21 12.200 12.60 4 1 18 1 2 IV 18.200 0.75 0.265 2.61 36.700 37.60 2 1 22 1 2 IV 4.140 0.75 0.451 1.54 7.860 8.15 2 1 23 1 2 IV 9.190 0.75 0.217 3.19 22.200 23.30 4 1 27 1 2 IV 2.120 0.50 0.340 2.04 4.820 5.13 2 1 28 1 2 IV 3.20 0.75 0.357 1.94 9.68 10.00 4 1 31 1 2 IV 1.89 0.75 0.280 2.48 5.98 6.44 2 1 33 1 2 IV 1.48 0.75 0.421 1.65 1.91 3.05 2 1 34 1 2 IV 1.38 3.00 0.437 1.59 5.34 5.67 4 1 37 1 2 IV 3.41 3.00 0.392 1.77 15.80 16.20 2 1 39 1 2 IV 3.18 0.50 0.231 3.00 5.58 6.48 4 2 908 1 2 IV 7.13 0.50 0.297 2.33 12.60 13.10 2 2 932 1 2 IV 13.00 0.25 0.219 3.17 20.80 21.60 4 2 1 2 2 IV 4.99 0.50 0.394 1.76 9.35 9.78 1 1 3 2 2 IV 1.20 3.00 0.236 2.94 4.76 5.64 3 1 5 2 2 IV 2.25 0.50 0.247 2.81 6.72 7.22 1 1 10 2 2 IV 1.22 3.00 0.406 1.71 5.07 5.55 3 1 12 2 2 IV 1.34 0.75 0.255 2.72 3.07 5.45 1 1 14 2 2 IV 5.42 0.75 0.371 1.87 16.70 17.30 3 1 15 2 2 IV 6.89 0.75 0.232 2.99 17.90 18.60 1 1 19 2 2 IV 14.30 0.75 0.296 2.34 32.40 33.10 1 1 20 2 2 IV 4.31 0.75 0.321 2.16 10.50 10.80 3 1 24 2 2 IV 4.94 0.75 0.204 3.39 15.10 15.90 1 1 25 2 2 IV 1.47 0.75 0.343 2.02 3.85 5.11 3 1 26 2 2 IV 2.22 0.50 0.350 1.98 4.78 6.36 1 1 29 2 2 IV 1.77 2.00 0.547 1.27 6.23 6.52 3 1 30 2 2 IV 2.91 0.50 0.311 2.23 5.48 7.94 1 1 35 2 2 IV 1.74 2.50 0.317 2.19 6.64 7.02 3 1 36 2 2 IV 4.32 0.75 0.399 1.74 12.20 12.50 1 1 38 2 2 IV 4.49 0.50 0.048 14.50 13.60 19.20 1 1 40 2 2 IV 7.89 0.75 0.449 1.54 20.50 20.80 3 2 906 2 2 IV 1.44 0.75 0.362 1.92 4.55 4.92 3 3 921 2 2 IV 7.05 2.50 0.323 2.15 24.50 25.10 3 3