Science & Research

Selected FDA Publications Related to Applications of Nanotechnology

2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006

2012

Chiang HM, Xia Q, Wang C, Wang S, Miller B, Howard PC, Yin JJ, Beland FA, Yu H, Fu PP. Nano-ZnO induces cytotoxicity and DNA damage in human cell lines and rat primary neuronal cells. J Nanosci Nanotechnol 2012; (In Press).

Dobrovolskaia MA, Patri AK, Simak J, Hall JB, Semberova J, De Paoli Lacerda SH, McNeil SE. Nanoparticle Size and Surface Charge Determine Effects of PAMAM Dendrimers on Human Platelets in Vitro. Mol Pharm 2012; 9(3):382-93.

Kamikawa TL, Mikolajczyk MG, Kennedy M, Zhong LL, Zhang P, Setterington EB, Scott DE, Alocilja EC. Pandemic Influenza Detection by Electrically Active Magnetic Nanoparticles and Surface Plasmon Resonance. IEEE Trans Nanotechnol 2012;11(1):88-96.

Karmakar A, Lancu C, Lancu DT, Mahmood MW, Ghosh A, Xu Y, Dervishi E, Collom SL, Mustafa T, Watanabe F, Fejleh A, Biris AR, Khodakovskaya M,  Zhang Y, Ali SF, Casciano D, Hassen S, Nima Z, Biris AS. Raman Spectroscopy as a Detection and Analysis Tool for In Vitro Specific Targeting of Pancreatic Cancer Cells by EGF-Conjugated Single Wall Carbon Nanotubes. J Applied Toxicology 2012 May; 32(5): 365-75.

Keene AM, Peters D, Rouse R, Stewart S, Rosen ET, Tyner KM. Tissue and cellular distribution of gold nanoparticles varies based on aggregation/agglomeration status. Nanomedicine 2012;7(2):199-209.

Kumar G, Waters MS, Farooque TM, Young MF, Simon CG Jr. Freeform fabricated scaffolds with roughened struts that enhance both stem cell proliferation and differentiation by controlling cell shape. Biomaterials 2012; (Epub ahead of print).

Liu J, Hu X, Hou S, Wen T, Liu W, Zhu X, Yin JJ, Wu X. Au@Pt core/shell nanorods with peroxidase- and ascorbate oxidase-like activities for improved detection of glucose.  Sensors & Actuators: B.Chemical 2012; (In Press).

Llorens A, Lloret E, Picouet, PA, Trbojevich R, and Fernandez A. Metallic-based micro and nanocomposites in food contact materials and active food packaging. Trends in Food Science and Technology 2012; 24:19-29.

Mei N, Ding W, Chen Y, Guo X, Zhang Y, Biris A, Rice P, Ali S, Aidoo A, Moore MM, Chen T. Silver nanoparticles induced genotoxicity and oxidative stress in mouse lymphoma cells. Environ Mol Mutagen 2012; (In Press).

Sadiq R., Bhalli JA, Yan J, Woodruff RS, Pearce MG, Li Y, Mustafa T, Watanabe F, Pack LM, Biris A, Khan OM, Chen, T. Genotoxicity of TiO2 anatase nanoparticles in B6C3F1 male mice evaluated using Pig-a and flow cytometric micronucleus assays. Mutat Res 2012; (Epub ahead of print).

Trickler WJ, Lantz SM, Schrand AM, Robinson BL, Newport GD, Schlager JJ, Paule MG, Slikker W, Biris AS, Hussain SM, Ali SF. Effects of copper nanoparticles on rat cerebral microvessel endothelial cells. Nanomedicine 2012; (Epub ahead of print).

Xu X, Khan MA, Burgess DJ. Predicting hydrophyllic drug encapsulation inside unilamellar liposomes. Int J Pharm 2012;423(2):410-8.

Xu X, Khan MA, Burgess DJ. A quality by design (QbD) case study on liposomes containing hydrophilic API: II. Screening of critical variables, and establishments of design space at laboratory scale. Int J Pharm 2012;423(2);543-53.

Yin, JJ, Zhao B, Xia Q, Fu P. “Electron Spin Resonance Spectroscopy for Studying the Generation and Scavenging of Reactive Oxygen Species by Nanomaterials” in Nanopharmaceuticals: The Pharmaceutical Application of Nanotechnology, World Scientific Publishing Co., Inc., 2012 (In Press).

2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006


2011

Austin CA, Umbriet TH, Brown KM, Barber DS, Dair BJ, Francke-Carroll S, Feswick A, Saint-Louis MA, Hikawa H, Siebein KN, Goering PL.  Distribution of silver nanoparticles in pregnant mice and developing embryos.  Nanotoxicology 2011; (Epub ahead of print).

Biris AR, Mahmood M, Lazar MD, Dervishi E, Watanabe F, Mustafa T, Baciut G, Baciut M, Bran S, Ali S, Biris AS. Novel Multicomponent and Biocompatible Nanocomposite Materials Based on Few-Layer Graphenes Synthesized on a Gold/Hydroxyapatite Catalytic System with Applications in Bone Regeneration. J Phys Chem C 2011; 115(39):18967-76.

Choi J, Reipa V, Hitchins VM, Goering PL, Malinauskas RA. Physicochemical characterization and in vitro hemolysis evaluation of silver nanoparticles. Toxicol Sci 2011;123(1):133-43.

De Paoli Lacerda SH, Semberova J, Holada K, Simakova O, Hudson SD, Simak J. Carbon nanotubes activate store-operated calcium entry in human blood platelets. ACS Nano 2011;5(7):5808-13.

Duncan T. The communications challenges presented by nanofoods. Nature Nanotechnol 2011; 6: 683-688.

Duncan TV. Applications of nanotechnology in food packaging and food safety: Barrier materials, antimicrobials and sensors. J Colloid Interface Sci 2011 Nov 1;363(1):1-24.

Fan J, Yin JJ, Ning B, Wu X, Hu Y, Ferrari M, Anderson GJ, Wei J, Zhao Y, Nie G. Direct evidence for catalase and peroxidase activities of ferritin-platinum nanoparticles. Biomaterials 2011;32(6):1611-8.

Gao Y, Gopee NV, Howard PC, Yu LR. Proteomic analysis of early response lymph node proteins in mice treated with titanium dioxide nanoparticles. J Proteomics 2011; 74(12):2745-59.

Guha S, Pease LF 3rd, Brorson KA, Tarlov MJ, Zachariah MR. Evaluation of electrospray differential mobility analysis for virus particle analysis: Potential applications for biomanufacturing. J Virol Methods 2011;178(1-2):201-8.

Gonzalez C, Salazar-Garcia S, Palestino G, Martinez-Cuevas PP, Ramirez-Lee MA, Jurado-Manzano BB, Rosas-Hernandez H, Gaytan-Pacheco N, Martel G, Espinosa-Tanguma R, Biris AS, Ali SF. Effect of 45 nm silver nanoparticles (AgNPs) upon the smooth muscle of rat trachea: role of nitric oxide. Toxicol Lett 2011;207(3):306-13.

He W, Liu Y, Yuan J, Yin JJ, Wu X, Hu X, Zhang K, Liu J, Chen C, Ji Y, Guo Y. Au@Pt nanostructures as oxidase and peroxidase mimetics for use in immunoassays. Biomaterials 2011;32(4):1139-47.

Jennings TL, Becker-Catania SG, Triulzi RC, Tao G, Scott B, Sapsford KE, Spindel S, Oh E, Jain V, Delehanty JB, Prasuhn DE, Boeneman K, Algar WR, Medintz IL. Reactive semiconductor nanocrystals for chemoselective biolabeling and multiplexed analysis. ACS Nano 2011;5(7):5579-93.

Jiang W, Lionberger R, Yu LX. In vitro and in vivo characterizations of PEGylated liposomal doxorubicin. Bioanalysis 2011;3(3):333-44.

Karmakar A, Xu Y, Mahmood MW, Zhang YB, Saeed LM, Mustafa T, Ali S, Biris AR, Biris AS. Radio-frequency induced in vitro thermal ablation of cancer cells by EGF functionalized carbon-coated magnetic nanoparticles. J Mater Chem 2011;21(34):12761-9.

Keene AM, Allaway RJ, Sadrieh N, Tyner K. Gold nanoparticle trafficking of typically excluded compounds across the cell membrane in JB6 Cl 41-5a cells causes assay interference. Nanotoxicology 2011;5(4) 469-78.

Keene AM, Tyner KM. Analytical Characterization of Gold Nanoparticle Primary Particles: Aggregates, Agglomerates and Agglomerated Aggregates. Journal of Nanoparticle Research 2011;13:3465-81.

Li Y, Chen DH, Yan J, Chen Y, Mittelstaedt RA, Zhang Y, Biris AS, Heflich RH, Chen T. Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay. Mutat Res 2011; (Epub ahead of print).

Mahmood M, Li Z, Casciano D, Khodakovskaya MV, Chen T, Karmakar A, Dervishi E, Xu Y, Mustafa T, Watanabe F, Fejleh A, Whitlow M, Al-Adami M, Ghosh A, Biris AS. Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation. J Cell Mol Med 2011;15(11):2297-306.

Martinez MN. Factors influencing the use and interpretation of animal models in the development of parenteral drug delivery systems. AAPS J 2011;13(4):632-49.

Mossoba MM, Chizhikov V, Volokhov DV, Martinez-Diaz Milians K, Schoen B, Al-Khaldi SF. Identification of Mycoplasmas Using a Fluorophore-Free Microarray and Infrared Chemical Imaging (IRCI). J Microbiol Methods 2011;86(3):383-6.

Mudalige TK, Linder SW. Development of screening methodologies for the detection of nanoscale silver in FDA regulated food products using inductively coupled plasma mass spectrometry (ICP-MS). FDA/ORA/DFS Laboratory Information Bulleting (LIB) #4514, 2011.

Narayan R, Goering P. Laser micro- and nanofabrication of biomaterials. MRS Bull 2011;36(12):973-82.

Oh E, Delehanty JB, Sapsford KE, Susumu K, Goswami R, Blanco-Canosa JB, Dawson PE, Granek J, Shoff M, Zhang Q, Goering PL, Huston A, Medintz IL. Cellular Uptake and Fate of PEGylated Gold Nanoparticles Is Dependent on Both Cell-Penetration Peptides and Particle Size. ACS Nano 2011;5(8):6434-48.

Sapsford KE, Spindel S, Jennings T, Tao G, Triulzi RC, Algar WR, Medintz IL. Optimizing Two-Color Semiconductor Nanocrystal Immunoassays in Single Well Microtiter Plate Formats. Sensors 2011;11(8):7879-7891.

Sapsford KE, Tyner KM, Dair BJ, Deschamps JR, Medintz IL. Analyzing nanomaterial bioconjugates: a review of current and emerging purification and characterization techniques. Analytical Chemistry 2011;88:4453-88.

Silbergeld EK, Contreras EQ, Hartung T, Hirsch C, Hogberg H, Jachak AC, Jordan W, Landsiedel R, Morris J, Patri A, Pounds JG, de Vizcaya Ruiz A, Shvedova A, Tanguay R, Tatarazako N, van Vliet E, Walker NJ, Wiesner M, Wilcox N, Zurlo J. Nanotoxicology: "The end of the beginning" - Signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials - t4 workshop report. ALTEX 2011;28(3):236-41.

Trickler WJ, Munt DJ, Jain N, Joshi SS, Dash AK. Antitumor efficacy, tumor distribution and blood pharmacokinetics of chitosan/glyceryl-monooleate nanostructures containing paclitaxel. Nanomedicine 2011;6(3):437-48.

Trickler WJ, Lantz SM, Murdock RC, Schrand AM, Robinson BL, Newport GD, Schlager JJ, Oldenburg SJ, Paule MG, Slikker Jr W, Hussain SM, Ali SF. Brain microvessel endothelial cells responses to gold nanoparticles: In vitro pro-inflammatory mediators and permeability. Nanotoxicology 2011;5:479-92.

Tsai DH, Delrio FW, Keene AM, Tyner KM, Maccuspie RI, Cho TJ, Zachariah MR, Hackley VA. Adsorption and Conformation of Serum Albumin Protein on Gold Nanoparticles Investigated Using Dimensional Measurements and in Situ Spectroscopic Methods. Langmuir 2011;27(6):2464-77.

Tyner KM, Sadrieh N. “Considerations when submitting nano-therapeutics to FDA/CDER for regulatory review” in Characterization of Nanoparticles Intended for Drug Delivery, McNeil S, ed. Humana Press, NJ, 2011.

Tyner KM, Wokovich AM, Godar DE, Doub WH, Sadrieh N. The state of nano-sized titanium dioxide (TiO2) may affect sunscreen performance. Int J Cosmet Sci 2011; 33(3):234-44.

Umbreit TH, Francke-Carroll S, Weaver JL, Miller TJ, Goering PL, Sadrieh N, Stratmeyer. Tissue distribution and histopathological effects of titanium dioxide nanoparticles after intravenous or subcutaneous injection in mice.  J Appl Toxicol 2011;32(5);350-7.

Wamer W, Yin, JJ, Photocytotoxicity Elicited by Permanent Makeup Inks Containing Titanium Dioxide Observed in Human Dermal Fibroblasts. J Cosmetic Science 2011; 62:535-47.

Xu X, Khan MA, Burgess DJ. A quality by design (QbD) case study on liposomes containing hydrophilic API: I. Formulation, processing design and risk. Int J Pharm 2011; 419(1-2):52-59.

Yang MH, Sun S, Kostov Y, Rasooly A. A simple 96-well microfluidic chip combined with visual and densitometry detection for resource-poor point of care testing. Sensors Actuators B Chem 2011;153(1):176-81.

Yang MH, Kwon S, Kostov Y, Rasooly A, Rao G, Ghosh U. Study of the biouptake of labeled single-walled carbon nanotubes using fluorescence-based method. Environ Chem Lett 2011;9(2):235-41.

Zhang K, Hu X, Liu J, Yin JJ, Hou S, Wen T, He W, Ji Y, Guo Y, Wang Q, Wu X.
Formation of PdPt Alloy Nanodots on Gold Nanorods: Tuning Oxidase-like Activities via Composition. Langmuir 2011;27(6):2796-803.

Zhang Q, Hitchins VM, Schrand AM, Hussain SM, Goering PL. Uptake of gold nanoparticles in murine macrophage cells without cytotoxicity or production of pro-inflammatory mediators. Nanotoxicology 2011;5:284-95.

Zhang Y, Xu Y, Li Z, Chen T, Lantz SM, Howard PC, Paule MG, Slikker W, Watanabe F, Mustafa T, Biris AS, Ali SF. Mechanistic toxicity evaluation of uncoated and PEGylated single-walled carbon nanotubes in neuronal PC12 cells. ACS Nano 2011;5(9):7020-33.

Zook JM, Rastogi V, Maccuspie RI, Keene AM, Fagan J. Measuring agglomerate size distribution and dependence of localized surface plasmon resonance absorbance on gold nanoparticle agglomerate size using analytical ultracentrifugation. ACS Nano 2011;5(10):8070-9.

2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006


2010

Agrawal A, Pfefer TJ, Gilani N, Drezek R. Three-dimensional characterization of optical coherence tomography point spread functions with a nanoparticle-embedded phantom. Opt Lett 2010;35(13):2269-71.

Boehmer JL, Degrasse JA, McFarland MA, Tall EA, Shefcheck KJ, Ward JL, Bannerman DD. The proteomic advantage: Label-free quantification of proteins expressed in bovine milk during experimentally induced coliform mastitis. Vet Immunol Immunopathol 2010;138(4):252-66.

Campbell L, Olson RJ, Sosik HM, Abraham A, Henrichs DW, Hyatt CJ, Buskey EJ.
First harmful Dinophysis (Dinophyceae, Dinophysiales) bloom in the U.S. is revealed by automated imaging flow cytometry. J Phycol 2010;46(1):66-75.

Dair BJ, Saylor DM, Cargal TE, French GR, Kennedy KM, Casas RS, Guyer JE, Warren JA, Kim CS, Pollack SK. The effect of substrate material on silver nanoparticle antimicrobial efficacy. J Nanosci Nanotechnol 2010;10(12):8456-62.

De Paoli Lacerda SH, Semberova J, Simakova O, Holada K, Gelderman MP, Simak J. Ultra-structural analysis of the interaction of carboxylated multi-walled carbon nanotubes with human blood platelets. Nanotech (NSTI) 2010;3:266-69.

Hong JS, Stavis SM, DePaoli Lacerda SH, Locascio LE, Raghavan SR, Gaitan M. Microfluidic directed self-assembly of liposome-hydrogel hybrid nanoparticles. Langmuir 2010;26(13):11581-8.

Kamikawa TL, Mikolajczyk MG, Kennedy M, Zhang P, Wang W, Scott DE, Alocilja EC. Nanoparticle-based biosensor for the detection of emerging pandemic influenza strains. Biosens Bioelectron 2010;26(4):1346-52.

Karanian JW, Peregoy JA, Chiesa OA, Murray TL, Ahn C, Pritchard WF. Efficiency of drug delivery to the coronary arteries in swine is dependent on the route of administration: assessment of luminal, intimal, and adventitial coronary artery and venous delivery methods. J Vasc Interv Radiol 2010;21(10):1555-64.

Lacerda SH, Park JJ, Meuse C, Pristinski D, Becker ML, Karim A, Douglas JF. Interaction of Gold Nanoparticles with Common Human Blood Proteins. ACS Nano 2010;4(1):365-79.
 

Liang X-J, Meng H, Wang Y, He H, Meng Jie, Lu J, Wang PC, Zhao Y, Gao X, Sun B, Chen C, Xing G, Shen D, Gottesman MM, Wu Y, Yin JJ, Jia L. Metallofullerene Nanoparticles Circumvent Tumor Resistance to Cisplatin by Reactivating Endocytosis. Proc Natl Acad Sci USA 2010;107:7449-7454.

McDermott MK, Saylor DM, Casas R, Dair BJ, Guo J, Kim CS, Mahoney CM, Ng K, Pollack SK, Patwardhan DV, Sweigart DA, Thomas T, Toy J, Williams CM, Witkowski CN. Microstructure and elution of tetracycline from block copolymer coatings. J Pharm Sci 2010;99(6):2777-85.

Mossoba MM, Al-Khaldi SF, Schoen B, Yakes BJ. Nanoparticle probes and mid-infrared chemical imaging for DNA microarray detection. Appl Spectrosc 2010;64(11):1191-8.

Mu L, Sprando RL. Application of nanotechnology in cosmetics. Pharm Res 2010;27(8):1746-9.

Prabhu BM, Ali SF, Murdock RC, Hussain SM, Srivatsan M. Copper nanoparticles exert size and concentration dependent toxicity on somatosensory neurons of rat. Nanotoxicology 2010;4(2):150-60.

Rahman Z, Zidan, AS, Habib MJ, Khan MA. Understanding the quality of protein loaded PLGA nanoparticles variability by Plackett-Burman design. Int J Pharm 2010;389(1-2):186-94.

Rahman Z, Zidan AS, Khan MA. Non-destructive methods of characterization of risperidone solid lipid nanoparticles. Eur J Pharm Biopharm 2010:76(1):127-37.

Rao SS, Ketha KMV, Atreya CD. Staphylococcus Aureus Detection In Platelets Using Short Synthetic Peptides Derived From Phage-Displayed Random Peptide Libraries Coupled with Quantum-Dot Nanocrystals. Blood 2010;116(21):1375-6.

Sadrieh N, Tyner KM. Nanotechnology and therapeutic delivery: a drug regulation perspective. Therapeutic Delivery 2010;1(1):83-9.

Sadrieh N, Wokovich AM, Gopee NV, Zheng J, Haines D, Parmiter D, Siitonen PH, Cozart CR, Patri AK, McNeil SE, Howard PC, Doub WH, Buhse LF. Lack of Significant Dermal Penetration of Titanium Dioxide (TiO2) from Sunscreen Formulations containing Nano- and Sub-Micron-Size TiO2 Particles. Toxicol Sci 2010;115(1):156-66.

Sainath Rao S, Mohan KV, Nguyen N, Abraham B, Abdouleva G, Zhang P, Atreya CD. Peptides panned from a phage-displayed random peptide library are useful for the detection of Bacillus anthracis surrogates B. cereus 4342 and B. anthracis Sterne. Biochem Biophys Res Commun 2010;395(1):93-8.

Schrand AM, Rahman MF, Hussain SM, Schlager JJ, Smith DA, Ali SF. Metal-based oxide nanoparticles and their toxicity Assessment. WIRE  Nanomed & Nanobiotech 2010;2: 544-68. 
 

Shah RB, Khan MA. “Emerging Nanodrugs- Design and Development Considerations. Nanomaterials: Properties, Preparation, and Processing” Cabra V, Silva R, eds.,  Nova Science Publisher, NY, 2010.

Sharma HS, Ali SF, Tian ZR, Patnaik R, Patnik S, Sharma A, Arne B, Per L, Elisabeth S, Torbjorn L. Nanowired drug delivery enhanced neuroprotective efficacy of compounds and reduces spinals cord edema formation and improves functional outcome following spinal cord injury in rats. Acta Neurochirurgica 2010;S106: 343-50.

Sharma,HS, Hussain SH, Schlager JJ, Ali SF, Sharma, A. Influence of nanoparticles on blood brain barrier permeability and brain edema formation in rats. Acta Neurochirurgica 2010;S106:359-64.

Sprando RL, Mu L. Application of Nanotechnology in Cosmetics. Pharm Res 2010;27(8):1746-9.

Stratmeyer ME, Goering PL, Hitchins VM, Umbreit TH. What we know and don't know about the bioeffects of nanoparticles: developing experimental approaches for safety assessment. Biomed Microdevices 2010;12(4):569-73.

Sun S, Yang M, Kostov Y, Rasooly A. ELISA-LOC: lab-on-a-chip for enzyme-linked immunodetection. Lab Chip 2010;10(16):2093-100.

Tang S, Hewlett I. Nanoparticle-Based Immunoassays for Sensitive and Early Detection of HIV-1 Capsid (p24) Antigen. J Infect Dis 2010;201(S1):S59-S64.

Tang S, Zhao J, Wang A, Viswanath R, Harma H, Little RF, Yarchoan R, Stramer SL, Nyambi PN, Lee S, Wood O, Wong EY, Wang X, Hewlett IK. Characterization of immune responses to capsid protein p24 of human immunodeficiency virus type 1 and implications for detection. Clin Vaccine Immunol 2010;17(8):1244-51.

Tang S, Zhao J, Wang A, Viswanath R, Harma H, Little R, Yarchoan R, Stramer S, Nyambi P, Lee S, Wood O, Wong E, Wang X, Hewlett I. Characterization of immune responses to capsid protein (p24) of Human Immunodeficiency Virus Type 1: Implications for early detection. Clin Vacc Immuno 2010;(Epub ahead of print). 

Teeparuksapun K, Hedstrom M, Wong EY, Tang S, Hewlett IK, Mattiasson B. Ultrasensitive Detection of HIV-1 p24 Antigen Using Nanofunctionalized Surfaces in a Capacitive Immunosensor. Anal Chem 2010;82(20):8406-11.

Trickler WJ, Lantz SM, Murdock RC, Schrand AM, Robinson BL, Newport GD, Schlager JJ, Oldenburg SJ, Paule MG, Slikker W Jr, Hussain SM, Ali SF. Silver nanoparticle induced blood-brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cells. Toxicol Sci 2010;118(1):160-70.

Volpe DA, Shaw RB, Chen XH, Zhou L, Chen ML. Effect of altered temperature storage on the in vitro cellular uptake of liposome drug products. J Liposome Res 2010;20(2): 178-82.

Xu Y, Karmakar A, Wang DY, Mahmood MW, Watanabe F, Zhang YB, Fejleh A, Fejleh P, Li ZR, Kannarpady G, Ali S, Biris AR, Biris AS. Multifunctional Fe3O4 Cored Magnetic-Quantum Dot Fluorescent Nanocomposites for RF Nanohyperthermia of Cancer Cells. J Phys Chem C 2010;114(11):5020-6.

Yang Y, Shah RB, Faustino PJ, Raw A, Yu LX, Khan MA. Thermodynamic stability assessment of a colloidal iron drug product: sodium ferric gluconate. J Pharm Sci 2010;99(1):142-53.

Yang M, Sun S, Kostov Y, Rasooly A. Lab-on-a-chip for carbon nanotubes based immunoassay detection of Staphylococcal Enterotoxin B (SEB). Lab Chip 2010;10(8):1011-7.

Yang M, Sun S, Bruck HA, Kostov Y, Rasooly A. Lab-on-a-chip for label free biological semiconductor analysis of Staphylococcal Enterotoxin B. Lab Chip 2010;10(19):2534-40.

Yang M, Bruck HA, Kostov Y, Rasooly A. Biological semiconductor based on electrical percolation. Anal Chem 2010;82(9):3567-72.

Yang M, Sun S, Bruck HA, Kostov Y, Rasooly A. Electrical percolation-based biosensor for real-time direct detection of staphylococcal enterotoxin B (SEB). Biosens Bioelectron 2010;25(12):2573-8.

Zhang Y, Ali SF, Dervishi E, Xu,Y, Li Z, Casciano D, Biris AS. Cytotoxicity Effects of Graphene and Single-Wall Carbon Nanotubes in Neural Phaeochromocytoma-Derived PC12 Cells. ACS Nano 2010;4(6):3181-6.

Zhao J, Tang S, Storhoff J, Marla S, Bao YP, Wang X, Wong EY, Ragupathy V, Ye Z, Hewlett IK. Multiplexed, rapid detection of H5N1 using a PCR-free nanoparticle-based genomic microarray assay. BMC Biotechnol 2010;10:74.

Zidan AS, Rahman Z, Habib MJ, Khan MA. Spectral and spatial characterization of protein loaded PLGA nanoparticles. J Pharm Sci 2010;99(3):1180-92.

Zolnik BS, Gonzalez-Fernandez A, Sadrieh N, Dobrovolskaia MA. Nanoparticles and the immune system. Endocrinology 2010;151(2):458-65.

2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006


2009

Choi J, Zhang Q, Reipa V, Wang NS, Stratmeyer ME, Hitchins VM, Goering PL. Comparison of cytotoxic and inflammatory responses of photoluminescent silicon nanoparticles with silicon micron-sized particles in RAW 264.7 macrophages. J Appl Toxicol 2009;29(1):52-60.

Dair BJ, Tyner KM, Sapsford KE. “Techniques for the characterization of nanoparticle-bioconjugates” in Nanoparticles in Bioengineering. Rege R, Medintz I, eds., Artech House. pp 293-333, 2009.

Dobrovolskaia MA, Germolec DR, Weaver JL. Evaluation of nanoparticle immunotoxicity. Nature Nanotechnology 2009;4:411-4.

Gopee, NV, Roberts DW, Webb P, Cozart CR, Siitonen PH, Latendresse JR, Warbritton AR, Yu WW, Colvin VL, Walker NJ, Howard PC. Quantitative determination of skin penetration of PEG-coated CdSe quantum dots in dermabraded but not intact SKH-1 hairless mouse skin. Toxicol Scis 2009;111(1):37-48.

Patri A, Umbreit T, Zheng J, Nagashima K, Goering P, Francke-Carroll S, Gordon E, Weaver J, Miller T, Sadrieh N, McNeil S, Stratmeyer M. Energy dispersive X-ray analysis of titanium dioxide nanoparticle distribution after intravenous and subcutaneous injection in mice. J Appl Toxicol 2009;29:662-72.

Rahman MF, Wang J, Patterson TA, Saini UT, Robinson BL, Newport GD, Murdock RC, Schlager JJ, Hussain SM, Ali SF. Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles. Toxicol Letters 2009;187:15-21.

Rosas-Hernandez H, Jumenez-Badillo S, Martinez-Cuevas P, Gracia-Espino E, Terrones H, Terrones M, Hussain SM, Ali SF, Gonzalez C.  Effects of 45-nm silver nanoparticles on conornary endotelial cells and isolated rat aortic rings. Toxicol Letters 2009;191:305-13.

Shah RB, Khan MA. “Regulatory aspects of nanomaterials in pharmaceutical industry” in Nano-Materials for Pharmaceutical Scientists. Yin S, Wei A, eds., John Wiley and Sons, 2009.

Semberova J, De Paoli Lacerda SH, Simakova O, Holada K, Gelderman MP, Simak J. Carbon nanotubes activate platelets by inducing extracellular Ca2+ influx sensitive to calcium entry inhibitors. Nano Letters 2009; 9(9):3312-17.

Sharma HS, Ali SF, Hussain SH, Schlager JJ, Sharma A. Influence of engineered nanoparticles from metals on the blood brain barrier permeability, cerebral blood flow, brain edema and neurotoxicity. An experimental study in the rat and mice using biochemical and morphological approaches. Neuroscience and Nanotechnology 2009; 9:5055-72.

Sharma HS, Ali SF, Tian ZR, Hussain SH, Schlager JJ, Sjoquist P, Sharma A, Muresanu, DF.  Chronic treatment with nanoparticles exacerbates hyperthermia induced blood brain barrier breakdown, cognitive dysfunction and brain pathology in the rat. Neuroprotective effects of nanowired-antioxidant compound H-290/51.  Neuroscience and Nanotechnology 2009;9:5073-90.

Sharma HS, Ali SF, Tian ZR, Patnaik R, Patnaik S, Lek P, Sharma A, Lundstedt T. Nano-Drug delivery and neuroprotection in spinal cord injury. Neuroscience and Nanotechnology 2009;9:5014-37.

Simak J. “Nanotoxicity in blood: Effects of engineered nanomaterials on platelets” in Nanotoxicity In Vivo and In Vitro Models to Health Risks. Sahu S, Casciano D, eds., John Wiley and Sons, pp 191-225, 2009.

Tyner KM, Wokovich AM, Doub WH, Buhse LF, Sung LP, Watson SS, Sadrieh N. Comparing methods for detecting and characterizing metal oxide nanoparticles in unmodified commercial sunscreens. Nanomed 2009;4:149-54.

Wang J, Rahman MF, Duhart HM, Newport GD, Patterson TA, Murdock RC, Hussain SM, Schlager JJ, Ali SF. Expression changes of dopaminergic system related genes in PC 12 cells induced by manganese, silver or copper nanoparticles. Neurotoxicology 2009;30: 926-33.

Wokovich AM, Tyner KM, Doub WH, Sadrieh N, Buhse .F. Particle size determination of sunscreens formulated with various forms of titanium dioxide. Drug Development and Industrial Pharmacy 2009;35(10):1180-9.

Yang M, Kostov Y, Bruck HA, Rasooly A. Gold nanoparticle-based enhanced chemiluminescence immunosensor for detection of Staphylococcal Enterotoxin B (SEB) in food. Int J Food Microbiol 2009;133(3):265-71.

Yin JJ, Lao F, Fu PP, Wamer WG, Zhao YL, Wang PCD, Han Y, Qiu B, Sun G, Liang XJ, Chen CY. Functionalized fullerene materials protect cells by potently scavenging reactive oxygen species. Biomaterials 2009;30:611-21.

Zhao B, He YY, Chignell CF, Yin JJ, Andley Y, Roberts JE.  Differences in phototoxicity of cyclodextrin complexed fullerene [(gamma-CyD)2/C60] and its aggregated derivatives toward human lens epithelial cells. Chem Res Toxicol 2009;22: 660-7.

Zhao B, Yin JJ, Bilski PJ, Chignell CF, Robert JE, He YY.  Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticles. Toxicol and Applied Pharm 2009; 241:163-73.

Zolnik BS, Sadrieh N. Regulatory perspective on the importance of ADME assessment of nanoscale material containing drugs. Adv Drug Deliv Rev 2009;61(6):422-7.

2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006


2008

Bronaugh RL, FDA Perspective On Topical Nanomaterials in Cosmetics, The Toxicologist, page 262, March 2008.

Gelderman MP, Simakova O, Clogston JD, Patri A, Siddiqui SF, Vostal AC, Simak, J. Adverse effects of fullerenes on endothelial cells: Fullerenol C60(OH)24 induced tissue factor and ICAM-1 membrane expression and apoptosis in vitro. Int J of Nanomedicine 2008;3(1): 59-68.

Kraeling MEK, Ogunsola OA, Bronaugh RL. In Vitro Penetration of Dendrimer Nanoparticles Through Human Skin, The Toxicologist, page 212, March 2008.

Shah RB, Khan MA. “Nanopharmaceuticals: challenges and regulatory overview” in Nanotechnology in Drug Delivery. DeVilleirs W, ed. Spring Science, NY, 2008.

Shah RB, Yang Y, Khan MA, Faustino PJ. Molecular weight determination for colloidal iron by Taguchi optimized validated gel permeation chromatography. Int J Pharm 2008; 353(1-2):21-7.

Yin JJ, Lao F, Meng J, Fu PP, Zhao Y, Xing G, Gao X, Sun B, Wang PC, Chen C, Liang XJ. Inhibition of tumore growth by endohedral metallofullerenol nanoparticles optimized as reactive oxygen species scavengers. Mol Phamacol 2008;74(4):1132-40.

Zidan AS, Sammour OA, Hammad MA, Megrab NA, Habib MJ, Khan MA. Quality by design: understanding the product variability of a self-nano-emulsified drug delivery system of cyclosporine A. J Pharm Sci 2008;96(9):2409-23.

2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006


2007

Gopee NV, Roberts DW, Webb P, Cozart CR, Siitonen PH, Warbritton AR, Yu WW, Colvin VL, Walker NJ, Howard PC. Migration of intradermally injected quantum dots to sentinel organs in mice. Toxicol Sci 2007;98(1):249-57.

Kraeling ME, Gopee NV, Roberts DW, Ogunsola OA, Walker NJ, Yu WW, Colvin VL, Howard PC, Bronaugh RL. Evaluation of In Vitro Penetration of Quantum Dot Nanoparticles into Human Skin, The Toxicologist, page 196, March 2007.

Shah, RB, Zidan AS, Funck T., Tawakkul MA, Nguyenpho A, Khan MA. Quality by design: characterization of self-nano-emulsified drug delivery systems (SNEDDs) using ultrasonic resonator technology. Int J Pharm 2007;341(1-2):189-94.

Sharma HS, Ali SF, Dong W, Tian ZR, Patnaik RL, Patnaik S, Sharma A, Boman A, Lek P, Seifert E, Lundstedt T. Drug Delivery to the spinal cord tagged with nanowire enhances neuroprotective efficacy and functional recovery following trauma to the rat spinal cord. Ann NY Acad Sci 2007;1122:197-218.

Zidan AS, Sammour OA, Hammad MA, Megrab NA, Habib MJ, Khan MA. Quality by design: understanding the formulation variables of a cyclosporine A self-nanoemulsified drug delivery systems by Box-Behnken design and desirability function. Int J Pharm 2007;332(1-2):55-63.

2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006


2006

Hussain, SM, Javorina AK, Schrand AM, Duhart HM, Ali SF, Schlager JJ. The interaction of manganese nanoparticles with PC-12 cells induces dopamine depletion. Toxicological Sci 2006;92(2):456-63.

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