• Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

Science & Research

  • Print
  • Share
  • E-mail

R/Bioconductor Installation Instructions for Linux/Unix systems

These instructions apply only to the installation of R/Bioconductor on  Linux/Unix sytems for ArrayTrack™. The installation on Windows platforms is completely automated within the application, so the following steps are not necessary on Windows.
  1. The Linux/Unix administrator should first install R (but not
    Bioconductor, yet) on the Linux/Unix machine. Any recent version
    should be fine. The easiest way is to use your distribution's package
    manager. If no such package is available, R can be installed by
    visiting http://www.r-project.org/ and follow the download/CRAN link on
    the left side to installation archives and instructions.
    The standard R installers will install the main parts of the R
    distribution someplace like /usr/lib/R. It should contain
    subdirectories like "bin", "lib", and "library" and a few others. We'll call this directory the R home directory.
  2. Now the administrator should switch to the user who will be running
    ArrayTrack™ if not already ("su - <username>"). This is important,
    because if logged in as root then Bioconductor will default to using a
    system-wide shared directory for its downloaded modules, which isn't
    writable by ordinary users, and this will cause failures later when the
    user does some kinds of processing that attempts to download into and/or modify this area.
  3. While logged in as the user who will run ArrayTrack™, start the R
    interpreter. If the R installer put the "R" command on your path (which it usually would), then you can just run "R":
    unpriv> R
    If R is not on your path, you will need to fully qualify the R command
    instead with the path to the R home (step 1), e.g.:
    unpriv> /usr/lib/R/bin/R
    Now within R, install Bioconductor with the following sequence of
    Commands:
    > source("http://www.bioconductor.org/biocLite.R");
    The following command may ask if it's OK to install modules in the
    user's home directory: say yes. This command may take a while.
    > biocLite();
    Support for the Plier algorithm isn't installed by default by the above,
    so we will install it separately. It may need come compiler components
    to be installed - if it fails for this reason, try installing these
    packages and trying this command again until it succeeds. If the Plier
    algorithm will not be used then this step may be skipped.
    > biocLite(c("plier"))
  4. ArrayTrack™ Setup
    To complete the setup, we need only to tell Local ArrayTrack™ where to find the R/Bioconductor distribution.
    • Non-prompted ArrayTrack™
      [ http://edkb.fda.gov/Webstart/extdb_arraytrack/3.4/ ]
      For the non-prompted ArrayTrack™, start the application as usual, then
      choose "configure connections..." from the main "database" menu at the
      top left of the application window. In the dialog, in field
      "R/BioConductor Location", enter the R home location as discussed in
      step 1 above, e.g. "/usr/lib/R". After restarting ArrayTrack™,
      R/Bioconductor functionality should be available to the user.
    • Prompted ArrayTrack™
      Please contact us if you need Linux/Unix Bioconductor support with the
      prompted login version of ArrayTrack™. You will need access to the jnlp
      launch file for this version of ArrayTrack™, which should be on one of
      your own Web servers.

This completes the R/Bioconductor setup for Linux/Unix distributions

 

Contact FDA

870-543-7000
National Center for Toxicological Research

Food and Drug Administration

3900 NCTR Road

Jefferson, AR 72079