Science & Research

FDA Grand Rounds

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The FDA Grand Rounds is webcast every other month to highlight cutting-edge research underway across the Agency and its impact on protecting and advancing public health. Each session features an FDA scientist presenting on a key public health challenge and how FDA is applying science to its regulatory activities. The 45-minute presentation is followed by questions from the audience. 

Non-FDA Attendees: 

Register here for remote access to webcast and CE credit  

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Thursday, November 10, 2016
12:00 to 1:00 p.m., Eastern Standard Time (EST)

Webcast Lecture

Metabolomics and Proteomics Biomarkers Discovery and Validation in Toxicity Studies

Presented by

Richard Beger, MS, PhD
Research Chemist
FDA’s National Center for Toxicological Research
Jefferson, Arkansas

About the Presentation

Metabolomics and proteomics technologies are being used in nonclinical and clinical studies to discover translational biomarkers in biofluids that would enable us to diagnose and predict toxicity before it occurs.  Dr. Beger will discuss the discovery of metabolomics and proteomics biomarkers following administration of acetaminophen in mice, rats, and children.  He will also discuss another study exploring biomarkers of doxorubicin cardiotoxicity. 

The metabolomics and proteomics biomarkers that have been identified to date have the potential to protect public health by enabling safer drug development and clinical management.  These biomarkers would provide us with earlier indications of toxicity and disease-induced damage in clinical and nonclinical studies.  

About the Presenter

Dr. Beger is an 18-year veteran of FDA’s National Center for Toxicological Research and an internationally recognized leader in toxicology. He uses computational modeling, metabolomics, and proteomics to  develop translational approaches to improve drug safety as well as disease detection and management.  Dr. Beger has made numerous groundbreaking advances in the area of metabolomic biomarker discovery. 

At the Arkansas Children’s Hospital in Little Rock, Arkansas, Dr. Beger has collaborated on metabolomics studies on biofluids of children without exposure to acetaminophen, upon therapeutic treatment, and in acetaminophen overdose situations. These studies found metabolic changes that translated between the preclinical and clinical studies. Dr. Beger is the 2016 winner of the prestigious Society of Toxicology Translational Impact Award.   

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